Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1369 | Thyroid (non-cancer) | ECE2017

Differential diagnosis between Anaplastic Thyroid Cancer and Primitive Lymphoma of the Thyroid gland: A 66-cases study

Kohler Florence , Vantyghem Marie-Christine , Carnaille Bruno , Leteurtre Emmanuelle , Boury Samuel , Terriou Louis , Do Cao Christine

A rapidly growing neoplastic mass of the neck can either be caused by an anaplastic thyroid cancer (ATC) or a primitive lymphoma of the thyroid gland (PLT). These two malignancies share the same clinical features but vary widely in their treatment and outcome. Only histologic criteria through biopsy can provide a definitive diagnosis. The aim of this study was to assess biological and radiological differences between ATC and PLT in order to hasten differential diagnosis. Sixty...

ea0020p190 | Endocrine tumours and neoplasia | ECE2009

Serum chromogranin A assay in the biological diagnosis of pheochromocytomas and/or paragangliomas: results in 146 patients

d'Herbomez Michele , Bauters Catherine , Caron Philippe , Do Cao Christine , Pigny Pascal , Leteurtre Emmanuelle , Carnaille Bruno , Wemeau Jean-Louis

The biological diagnosis of pheochromocytoma (P) and/or paraganglioma (Pgg) relies on the identification of excessive secretion of the metanephrines. Chomogranin A (CgA) is a general indicator of neuroendocrine tumours that is highly expressed in P and correlate with tumour mass and secretory activity. The CgA test could be indicated as a useful test in patients with false positive metanephrines results. The aim of our prospective bi-centre study, is to evaluate the performanc...

ea0032p557 | Endocrine tumours and neoplasia | ECE2013

Aggressive adreno-cortical carcinoma (ACC) associated with two rectal tumors (adenocarcinoma and neuro-endocrine) and somatic Kras mutation without microsatellite instability: is there a link?

Leroy Clara , DoCao Christine , Karrouz Wassila , Le Guillou Anne-Claire , Derveaux Alexandra , Buisine Marie-Pierre , Perbet R , Leteurtre Emmanuelle , Caiazzo Robert , Pattou Francois , Vantyghem Marie-Christine

Aggressive adreno-cortical carcinoma (ACC) is a rare, aggressive malignancy, with poorly understood molecular pathogenesis. As a result, therapeutic options are currently limited, surgery being currently the lone curative modality. Most cases of ACC are sporadic, although some familial cancer syndromes (Li–Fraumeni, Beckwith–Wiedemann, MEN1, Carney complex, congenital adrenal hyperplasia, etc.) are associated with an increased incidence of ACC. The genes involved in ...

ea0032p560 | Endocrine tumours and neoplasia | ECE2013

Clinical, biochemical, genetic and histological features of composite pheochromocytoma/ganglioneuroma adrenal tumors: a series of seven cases from two French academic centres

Bertron Alice , Gobet Francoise , Louiset Estelle , Tetsi-Nomigni Milene , Grumolato Luca , Leteurtre Emmanuelle , Grise Philippe , Yon Laurent , Wemeau Jean-Louis , Lefebvre Herve

Introduction: Adrenal pheochromocytomas have the same embryonic origin, i.e. the neural crest, as peripheral neuroblastic tumors such as ganglioneuromas, ganglioneuroblastomas and neuroblastomas. Ganglioneuromas are benign and silent tumors in that they usually do not secrete catecholamines in contrast to pheochromocytomas. Rarely, they can associate with pheochromocytomas to form composite tumors.Patients and methods: We have retrospectively studied sev...

ea0014p101 | (1) | ECE2007

Cigarette smoking increases high calcitonin levels

d’Herbomez Michele , Bauters Catherine , Leclerc Laurence , Leteurtre Emmanuelle , Carnaille Bruno , Schlienger Jean-Louis , Caron Philippe , Wémeau Jean-Louis

Increased basal or pentagastrin-stimulated calcitonin level is the cornerstone for the biological diagnosis of medullary thyroid carcinoma, but is also observed in patients with C-cell hyperplasia (CCH) of the thyroid. In a prospective multicenter study we re-evaluated the reference ranges of basal calcitonin (bCT) in 287 euthyroid controls without thyroid disease (142 men-45 smokers, 3 deprived, 145 women-27 smokers). The CT levels were measured using 2 different assays (Cis-...

ea0084op-07-34 | Oral Session 7: Thyroid Cancer Basic | ETA2022

CDK4 phosphorylation status and rational use of CDK4/6 inhibitors in advanced thyroid cancers

Pita Jaime M , Coulonval Katia , Costante Giuseppe , Myriam Decaussin , Emmanuelle Leteurtre , Cavaco Branca , A Copland John , Durante Cosimo , Maenhaut Carine , Dumont Jacques , Roger Pierre , Raspe Eric

Introduction and objectives: The cyclin-dependent kinases CDK4 and CDK6 are key regulators of the cell cycle entry, by phosphorylating the onco-suppressor retinoblastoma protein (pRb). CDK4/6 inhibitors (CDK4i) are already established as standard first-line treatment against advanced Estrogen Receptor-positive breast tumors, and have emerged as novel drugs to treat various pRb-proficient chemotherapy-resistant cancers. Presence of activating T172-phosphorylation of CDK4 in bre...

ea0041ep589 | Endocrine tumours and neoplasia | ECE2016

Proposal of a two-step dynamic prognostic stratification for stage IV sporadic pancreatic neuroendocrine tumors

Marotta Vincenzo , Walter Thomas , Do Cao Christine , Tafuto Salvatore , Montesarchio Vincenzo , Arfi-Rouche Julia , Valette Pierre Jean , Lombard-Bohas Catherine , Leteurtre Emmanuelle , Borget Isabelle , Scoazec Jean Yves , Ducreux Michel , Faggiano Antongiulio , Colao Annamaria , Baudin Eric

Purpose: To validate a prognostic stratification system of overall survival (OS) in stage IV pancreatic neuroendocrine tumors (pNETs) naïve of therapy by analyzing 1) prognostic parameters at the time of stage IV diagnosis; 2) the role of spontaneous tumor slope.Patients and Methods: Multicenter retrospective study including consecutive patients diagnosed with stage IV pNET from January 1997 to March 2014. Inclusion criteria were: 1. pNET w...