Searchable abstracts of presentations at key conferences in endocrinology

ea0050n2.1 | Nurse Session 2: Diabetes Insipidus | SFEBES2017

Clinical Presentation and Diagnosis of Cranial Diabetes Inspidus

Levy Miles

Cranial Diabetes Insipidus is a potentially fatal disorder if not diagnosed and treated appropriately. The diagnosis can either be made in the outpatient setting, whereby the main differential diagnosis is Primary Polydipsia (PP), or during a hospital admission, where patients can be prfoondly unwell, dehydrated and hypernatraemic. In the ouptatient setting, it can sometimes be difficult to distinguish between DI and PP, but usually severe Cranial DI is clinically and biochemi...

ea0050n2.1 | Nurse Session 2: Diabetes Insipidus | SFEBES2017

Clinical Presentation and Diagnosis of Cranial Diabetes Inspidus

Levy Miles

Cranial Diabetes Insipidus is a potentially fatal disorder if not diagnosed and treated appropriately. The diagnosis can either be made in the outpatient setting, whereby the main differential diagnosis is Primary Polydipsia (PP), or during a hospital admission, where patients can be prfoondly unwell, dehydrated and hypernatraemic. In the ouptatient setting, it can sometimes be difficult to distinguish between DI and PP, but usually severe Cranial DI is clinically and biochemi...

ea0021cm2.2 | Endocrine incidentalomas: what to do with lumps and bumps | SFEBES2009

Pituitary incidentalomas

Levy Miles

Background: Incidentally discovered pituitary lesions are a common problem in the endocrinology clinic due to increased access to detailed brain imaging. The challenge for endocrinologists is to determine which pituitary lesions are clinically significant and which are truly incidental. Pituitary micro-adenomas have been found at autopsy in 1.5–27% of subjects, whilst population-based radiological studies report small pituitary lesions in ~10%. It is difficult to produce ...

ea0048wa7 | Workshop A: Disorders of the hypothalamus and pituitary | SFEEU2017

CSF leak with dopamine agonist

Alam Kazi , Levy Miles

A 48-year-old gentleman was admitted to AMU overnight in January’12 from eye casualty with weeks of worsening visual disturbances followed by rapid deterioration – complete loss of vision in the right eye and a temporal hemianopia on the left side but no headache.Urgent hormone profile revealed elevated prolactin 53 988 mU/l, low testosterone of 3.3, SHBG 22, LH 2, FSH 3.1, IGF1 292, satisfactory SST (0 min cortisol 213 with ACTH 10 and 30 min ...

ea0055cb8 | Additional Cases | SFEEU2018

Peripartum calcium conundrum in a lady with pseudohypoparathyroidism

Aslam Muhammad Waseem , Levy Miles

Pseudohypoparathyroidism during pregnancy can lead to challenging calcium fluctuations and can lead to maternal and foetal morbidity. There are limited case reports and no established management guidelines. Maintaining calcium level in healthy range during pregnancy is required to minimise the risks of associated complications. We report a case of Pseudohypoparathyroidism type 1a in 30 year old lady, who was initially referred to us by her general physician with calcium, of 1....

ea0055wd5 | Workshop D: Disorders of the thyroid gland (II) | SFEEU2018

Hashimoto’s Thyroiditis and Thyroid cancer

Alam Kazi , Bhake Ragini , Levy Miles

A 40 year old lady presented to GP with few months history of palpitation, anxiety, frequent stools in April’15. Clinical examination revealed moderate sized goitre, more prominent on right side, mobile, non-tender and no lymphadenopathy. Blood tests consistent with T3 toxicosis with FT3 10 (3.5–6.5), FT4 21 (9–25), TSH <0.05 (0.3–5.0) and thyroid peroxidase antibody positive at 562 IU/ml (0–60). Initiated on Carbim...

ea0050cc07 | Featured Clinical Cases | SFEBES2017

Case report of MAX mutation causing bilateral phaeochromocytoma

Nazareth Joshua , Levy MIles , Barwell Julian

Background: Patients with Phaeochromocytomas (PCC) have been found to carry germline mutations in 40% of cases. The number of known susceptibility genes has risen sharply in recent times, from six to sixteen since 2009. We present a patient who was found to have a mutation in Myc Associated Protein X (MAX), one of the newly identified inherited susceptibility genes.Case Presentation: A 16-year-old female presented with paroxysmal episodes suggestive of c...

ea0050cc07 | Featured Clinical Cases | SFEBES2017

Case report of MAX mutation causing bilateral phaeochromocytoma

Nazareth Joshua , Levy MIles , Barwell Julian

Background: Patients with Phaeochromocytomas (PCC) have been found to carry germline mutations in 40% of cases. The number of known susceptibility genes has risen sharply in recent times, from six to sixteen since 2009. We present a patient who was found to have a mutation in Myc Associated Protein X (MAX), one of the newly identified inherited susceptibility genes.Case Presentation: A 16-year-old female presented with paroxysmal episodes suggestive of c...

ea0065cc7 | (1) | SFEBES2019

Arg798Ter BRIP-1 mutation associated with metastatic phaeochromocytoma

Gohil Shailesh , Barwell Julian , Levy Miles

Case: A 69 year old gentleman with a past medical history of essential hypertension presented to medical services with symptoms of weight loss, muscle weakness and fatigue. Following blood tests, a CT scan, liver biopsy and biochemical screening, a metastatic phaeochromocytoma was diagnosed. He was commenced on alpha and beta blockade. Further imaging, including a MIBG scan, showed non-resectable disease therefore he underwent therapeutic MIBG treatment. Following a good respo...

ea0063p329 | Reproductive Endocrinology 1 | ECE2019

Randomised Controlled Trials in women with polycystic ovary syndrome do not represent the majority of patients who are in a primary care setting: systematic review and meta-analysis

Liarakos Alexandros Leonidas , Levy Miles , Mani Hamidreza

Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with important long term health consequences such as higher chance of developing Type 2 diabetes, reduced overall wellbeing with poor quality of life. Such a common condition is mainly treated and investigated in the primary care setting.We therefore set out to see if the randomized controlled trials (RCT) represent the most common setting of care.<p class="abstex...