Searchable abstracts of presentations at key conferences in endocrinology

ea0016p500 | Obesity | ECE2008

Retinol-binding protein 4 (RBP-4) levels do not change after oral glucose tolerance test in obese and overweight individuals, but correlate with some indices of insulin resistance

Lewandowski Krzysztof C , Basinska-Lewandowska Magdalena , Bienkiewicz Malgorzata , Randeva Harpal S , Lewinski Andrzej

Background: Secretory products from adipocytes may contribute to increased insulin resistance (IR). Retinol-binding protein-4 (RBP-4) may increase IR in mice, with elevated levels in insulin resistant mice and humans with obesity and type 2 diabetes. Mechanisms regulating RBP-4 synthesis remain not fully understood. It is not clear whether short-term hyperglycaemia alters RBP-4 levels in humans. In order to investigate this, we measured serum RBP-4 concentrations during 75 gra...

ea0056p911 | Female Reproduction | ECE2018

Assessment of insulin resistance in polycystic ovary syndrome: HOMA, QUICKI and McAuley indices have only moderate correlation with OGTT-based belfiore index

Lewandowski Krzysztof C , Plusajska Justyna , Bieniek Ewa , Horzelski Wojciech , Lewinski Andrzej

Backgroud: Though insulin resistance (IR) is common in polycystic ovary syndrome (PCOS), there is no agreement as to what surrogate method of assessment of IR is most reliable.Aim: We compared methods based on measurements of fasting insulin and either fasting glucose (HOMA-IR and QUICKI), or triglycerides (TAG) (McAuley index) with insulin resistance (Belfiore) index (IRI) derived from glucose and insulin during a 75-g oral glucose tolerance test (OGTT)...

ea0019oc23 | Cardiovascular metabolism | SFEBES2009

Insulin increases and metformin decreases the novel adipokine chemerin in insulin resistant subjects: PCOS as a paradigm

Tan Bee , Chen Jing , Adya Raghu , Kaur Jaspreet , Heutling Dennis , Lewandowski Krzysztof C , Lehnert Hendrik , Randeva Harpal

Adipose tissue produces several hormones and cytokines termed ¬Ďadipokines¬í that have widespread effects on carbohydrate and lipid metabolism. They appear to play an important role in the pathogenesis of insulin resistance, diabetes, and atherosclerosis. Chemerin is a novel adipokine, highly expressed in obese, insulin-resistant subjects. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. We assessed chemerin levels in sera and adipose...