Searchable abstracts of presentations at key conferences in endocrinology

ea0031p383 | Thyroid | SFEBES2013

Case report: when measured free T4 and free T3 may be misleading. Interference with free thyroid hormones measurements on Roche and Siemens platforms

Lewandowski Krzysztof , Dabrowska Katarzyna , Lewinski Andrzej

A 59-year-old female presented with apathy and 6 kg weight gain. Investigations revealed primary hypothyroidism (TSH >100 μIU/ml). Thyroxine (L-T4) was started and titrated up to 75 μg, o.d., with clinical improvement. Other investigations revealed high titres of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After three months, there was a fall in TSH to 12.74 μIU/ml, however, with unexpectedly high free T4 (...

ea0020p116 | Thyroid | ECE2009

Application of flow cytometry for evaluation of the phenotype of lymphocytes, present in the thyroid glands of patients with lymphoma in extrathyroid localisation

Adamczewski Zbigniew , Dabrowski Jan , Lewinski Andrzej

Introduction: Cytological diagnostics has got an established position in thyroid diseases. In the recent years, attempts have been undertaken to use the biological material, left in needles after cytological preparation is ready, to obtain additional diagnostic data.Goal of study: The goal of the study was evaluation of the possibility to use the results of fine-needle aspiration biopsy (FNAB) for confirmation of either the presence or the absence of lym...

ea0016p295 | Endocrine tumours | ECE2008

Melatonin restores the basal level of lipid peroxidation in rat tissues under conditions of exposure to potassium bromate

Stasiak Magdalena , Lewinski Andrzej , Karbownik-Lewinska Malgorzata

Potassium bromate (KBrO3) is a known prooxidant and carcinogen. Melatonin is a highly effective antioxidant. Indole-3-propionic acid (IPA) – an indole substance, and propylothiouracil (PTU) – an antithyroid drug, also reveal some antioxidative effects. The aim of the study was to evaluate KBrO3-induced lipid peroxidation in vitro in tissues collected from either control or melatonin-treated rats, and to compare potential preventive effect...

ea0077p249 | Thyroid | SFEBES2021

Pulse methylprednisolone as preparation for thyroidectomy for drug-resistant amiodarone-induced thyrotoxicosis

Lewandowski Krzysztof , Dabrowska Katarzyna , Gluchowska Monika , Lewinski Andrzej

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

ea0049ep1325 | Thyroid (non-cancer) | ECE2017

The manner of performing the thyroid ultrasound examination and the reliability of assessment of the thyroid size in school-aged children

Zygmunt Arkadiusz , Adamczewski Zbigniew , Karbownik-Lewinska Malgorzata , Lewinski Andrzej

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

ea0049ep1435 | Thyroid (non-cancer) | ECE2017

K1 cell line in vitro: the impact of diagnostic absorbed doses from 131I

Stasiolek Mariusz , Adamczewski Zbigniew , Karwowski Boleslaw , Dedecjus Marek , Lewinski Andrzej

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

ea0059ep55 | Clinical practice, governance & case reports | SFEBES2018

Hypogonadism and acute hepatitis caused by ingestion of epistane (EAST®) for body-building purposes

Lewandowski Krzysztof , Kawalec Joanna , Dębrowska Katarzyna , Lewinski Andrzej

Background: Self-administration of anabolic steroids among bodybuilders is an underestimated problem, often not admitted by patients.Case presentaation: A 19 year old male (planning to study medicine!) presented with gynaecomastia, general malaise and erectile problems. Investigations revealed acute hepatitis: ALT 2125 U/L [Ref. range (RR)<45] and hypogonadotropic hypogonadism: LH – 1.6 IU/L [RR: 1.5-9.3], testosterone 0.214 ng/mL [RR: 2.49-8.36...

ea0035p793 | Paediatric endocrinology | ECE2014

Effectiveness of GH therapy in children with normal results of GH stimulation tests and with partial GH deficiency is similar and depends on the severity of IGF1I deficiency

Smyczynska Joanna , Stawerska Renata , Lewinski Andrzej , Hilczer Maciej

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

ea0034p54 | Clinical practice/governance and case reports | SFEBES2014

Thyrotoxicosis after severe hypothyroidism in a patient with a history of Hodgkin's lymphoma and neck irradiation

Lewandowski Krzysztof , Dabrowska Katarzyna , Makarewicz Jacek , Lewinski Andrzej

Background: Neck irradiadion is associated with several complications including both hypo- and hyperthyroidism. We present a case of severe hypothyroidism, followed 5 years later by thyrotoxicosis.Case description: A 27-year-old female presented with clinical and biochemical thyrotoxicosis (TSH 0.01 μIU/ml (ref. range: 0.27–4.2 μIU/ml); FreeT4 1.58 ng/dl (ref. 0.98–1.63 ng/dl); FreeT3 4.56 pg/ml (ref. 2.6–4....

ea0032p791 | Paediatric endocrinology | ECE2013

GH treated children with IGF1 deficiency and excluded GH insensitivity despite normal GH secretion may attain similar final height as children with GH deficiency

Smyczynska Joanna , Lewinski Andrzej , Stawerska Renata , Hilczer Maciej

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...