Endocrine Abstracts

A 59-year-old female presented with apathy and 6 kg weight gain. Investigations revealed primary hypothyroidism (TSH >100 μIU/ml). Thyroxine (L-T4) was started and titrated up to 75 μg, o.d., with clinical improvement. Other investigations revealed high titres of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After three months, there was a fall in TSH to 12.74 μIU/ml, however, with unexpectedly high free T4 (...

Introduction: Cytological diagnostics has got an established position in thyroid diseases. In the recent years, attempts have been undertaken to use the biological material, left in needles after cytological preparation is ready, to obtain additional diagnostic data.Goal of study: The goal of the study was evaluation of the possibility to use the results of fine-needle aspiration biopsy (FNAB) for confirmation of either the presence or the absence of lym...

Potassium bromate (KBrO3) is a known prooxidant and carcinogen. Melatonin is a highly effective antioxidant. Indole-3-propionic acid (IPA) – an indole substance, and propylothiouracil (PTU) – an antithyroid drug, also reveal some antioxidative effects. The aim of the study was to evaluate KBrO3-induced lipid peroxidation in vitro in tissues collected from either control or melatonin-treated rats, and to compare potential preventive effect...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

Background: Self-administration of anabolic steroids among bodybuilders is an underestimated problem, often not admitted by patients.Case presentaation: A 19 year old male (planning to study medicine!) presented with gynaecomastia, general malaise and erectile problems. Investigations revealed acute hepatitis: ALT 2125 U/L [Ref. range (RR)<45] and hypogonadotropic hypogonadism: LH – 1.6 IU/L [RR: 1.5-9.3], testosterone 0.214 ng/mL [RR: 2.49-8.36...

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Background: Neck irradiadion is associated with several complications including both hypo- and hyperthyroidism. We present a case of severe hypothyroidism, followed 5 years later by thyrotoxicosis.Case description: A 27-year-old female presented with clinical and biochemical thyrotoxicosis (TSH 0.01 μIU/ml (ref. range: 0.27–4.2 μIU/ml); FreeT4 1.58 ng/dl (ref. 0.98–1.63 ng/dl); FreeT3 4.56 pg/ml (ref. 2.6–4....

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...