Abstract Search

ea0065oc5.2 | Adrenal and Cardiovascular | SFEBES2019

Subclinical alpha-1 antitrypsin deficiency is associated with increased free cortisol fraction in plasma

Boyle Luke D , Nixon Mark , Hill Lesley A , Hammond Geoffrey L , Lewis John G , Stimson Roland H , Walker Brian R

Background: Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and controls the circulating free cortisol pool. Proteolytic cleavage by neutrophil elastase is proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. The CORtisol NETwork (CORNET) consortium found that genetic variation at a locus spanning SERPINA1 (encoding alpha-1 antitrypsin, A1AT, the endogenous inhibitor of neutrophil elastase) and SE...

0 shares

ea0081p283 | Adrenal and Cardiovascular Endocrinology | ECE2022

A single dose of Neutrophil Elastase inhibitor Elafin does not alter CBG cleavage during post-surgical stress in humans in vivo

Boyle Luke D , Nixon Mark , Underhill Caroline , Hill Lesley A , Lewis John G , Hammond Geoffrey L , Wiedow Oliver , Henriksen Peter A , Stimson Roland H , Walker Brian R

Introduction: Corticosteroid Binding Globulin (CBG) binds >85% of plasma cortisol and modulates free cortisol levels. Observations in vitro show that CBG is cleaved by neutrophil elastase (NE), a mechanism proposed to reduce CBG binding affinity and increase free cortisol availability to inflamed tissues. However, detection of cleaved CBG in vivo in human plasma is controversial, and any influence of NE on CBG cleavage has not been tested in vivo...

1 shares

Endocrine Abstracts

Subclinical alpha-1 antitrypsin deficiency is associated with increased free cortisol fraction in plasma

A single dose of Neutrophil Elastase inhibitor Elafin does not alter CBG cleavage during post-surgical stress in humans in vivo

BiosciAbstracts