ea0011oc7 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006
Lewis MD
, Easter TE
, Elford C
, Ludgate ME
, Evans BAJ
, Rees DA
, Scanlon MF
GH has diverse direct effects including the induction of lipolysis in adipocytes and mineralisation in bone. Interestingly, pluripotent mesenchymal stem cells can be isolated and cultured from adult bone marrow and induced to differentiate in vitro to both adipocytes and osteoblasts. GHR activation can be coupled to JAK2/STAT5 and the ERK (MAPK) pathway. We have therefore studied the evolution of GHR-associated cell signalling in adult rat BMSCÂ’s during differentia...