Searchable abstracts of presentations at key conferences in endocrinology

ea0013p152 | Diabetes, metabolism and cardiovascular | SFEBES2007

Effect of SOM230 on the proliferation of adult human vascular endothelial cells

Li Chao , Zhong Wenwen , Xu Shang-Zhong , Atkin Stephen L

SOM230 is one of the long-acting somatostatin analogues, which has been developed for the treatment of neuroendocrine tumours. Recently we found that SOM230 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). The aim of this study is to further investigate its antiproliferative effect using adult human aortic endothelial cells (HAECs) and human dermal microvessel endothelial cells (HDMECs). The expression of SSTRs and the potential mechanism were obs...