Searchable abstracts of presentations at key conferences in endocrinology

ea0035p347 | Diabetes (epidemiology, pathophysiology) | ECE2014

Risk of diabetes mellitus after first-attack acute pancreatitis: a national population-based study

Shen Hsiu-Nien , Yang Chun-Chieh , Chang Ya-Hui , Lu Chin-Li , Li Chung-Yi

Objective: We longitudinally assessed the overall and age- and sex-specific incidence rates and relative risks of newly diagnosed diabetes mellitus in patients surviving the first-attack acute pancreatitis (AP) as compared to matched controls.Methods: Study cohort included 2966 AP patients and 11 864 non-AP controls individually matched on age, sex and date of index admission, with an AP/non-AP ratio of 1:4. Incidence rate was estimated under Poisson ass...

ea0035p491 | Diabetes therapy | ECE2014

The favourable effects of autologous hematopoietic stem cell transplantation on the immune system in patients with type 1 diabetes

Li Li , Gu Weiqiong , Ye Lei , Yang Minglan , Wan Bin , Hong Jie , Wang Weiqing , Ning Guang

Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a promising treatment to reverse type 1 diabetes (T1D) in patients with significantly improved β-cell function. This study was designed to investigate the potential immunological mechanisms involved.Design and methods: 18 newly-diagnosed T1D were divided into two groups, the AHSCT group and the insulin therapy group. Blood mononuclear cells (PBMCs) of the patients at the baseli...

ea0020p357 | Diabetes and Cardiovascular | ECE2009

Pharmacokinetics of the dipeptidyl peptidase-4 inhibitor saxagliptin in subjects with renal impairment

Boulton David , Tang Angela , Patel Chirag , Li Li , Xu Xiaohui , Frevert Ernst , Kornhauser David

Background/aims: Saxagliptin is a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme. Saxagliptin is cleared by both metabolism and renal excretion. The aims of this study were to determine the effect of renal impairment (RI) and haemodialysis (HD) on the pharmacokinetics of saxagliptin.Methods: This open-label, parallel-group study was conducted in subjects with normal renal func...

ea0035p387 | Diabetes (epidemiology, pathophysiology) | ECE2014

The HLA-A*33 haplotype enhances the risk of type 1 diabetesin ndividuals with HLA-DR3+ or DR9+ haplotype

Zhang Juanjuan , Gu Weiqiong , Wang Bokai , Gao Jie , Li Li , Cui Bin , Hong Jie , Wang Weiqing , Ning Guang

Background: To investigate the typing for HLA-I in Chinese patients with type 1 diabetes (T1D) as a complement screening for HLA-II.Methods: A total of 212 T1D patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA-I and II were examined with a high-resolution polymerase chain reaction-sequence-based typing method.Results: The novel haplotype, A*33:03-B*58:01-C*03:02(A33), was a...