Searchable abstracts of presentations at key conferences in endocrinology

ea0020p25 | Adrenal | ECE2009

Towards an aldosterone producing cell line from an aldosterone producing adenoma

Lichtenauer Urs , Zwermann Oliver , Shapiro Igor , Mussack Thomas , Reincke Martin , Beuschlein Felix

To date, the in depth analysis of the key molecular mechanisms involved in functional autonomy and tumor formation in aldosterone producing adenomas has been hampered by the rarity of the disease and the lack of adequate tumor cell lines. Herein, we cultivated a primary cell culture of an aldosterone producing adenoma taken from a 40 year old male patient with a left sided adrenal tumor mass. The cells have been passaged 24 times and still continue to grow after nearly 11 mont...

ea0014p112 | (1) | ECE2007

Isolation of the Side population (SP) from murine adrenal glands renders cells with adrenocortical stem cell properties

Lichtenauer Urs , Shapiro Igor , Geiger Klaus , Pulichino Anne-Marie , Drouin Jaques , Beuschlein Felix

Radioactive and transgenic tracing experiments indicate that in the adult adrenal stem cells persist in the periphery of the cortex, which migrate centripetally and populate the inner cortical zones upon differentiation. However, investigation of these cells has been hampered by the lack of known marker genes. Vital Hoechst dye exclusion has been described as a method for isolating a side population (SP) from mouse bone marrow, which was enriched with stem cells. Utilizing thi...

ea0041oc14.5 | Thyroid Cancer | ECE2016

Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma in Germany: a retrospective multi-center study

Wendler Julia , Kroiss Matthias , Gast Katja , Kreissl Michael , Allelein Stephanie , Lichtenauer Urs , Blaser Rainer , Kuhn Klaus , Spitzweg Christine , Fassnacht Martin , Fuhrer Dagmar , Schott Matthias , Tiedje Vera

Context: Anaplastic (ATC) thyroid carcinoma is an orphan disease accounting for about 2% of all malignant thyroid tumors. ATC confers a dismal prognosis and standard treatment is not established.Objective: To describe the epidemiology, current treatment regimens and outcome of ATC, to identify clinical prognostic markers and treatment factors associated with improved prognosis. To establish a consensus treatment schedule.Design: Re...