Searchable abstracts of presentations at key conferences in endocrinology

ea0079004 | Abstracts | BES2021

Effect of glucocorticoid vs CRH treatment during sepsis on pituitary ACTH processing

Arno Teblick , Lauren De Bruyn , Perre Sarah Vander , Lies Langouche , Greet Van den Berghe

Purpose: Sepsis is hallmarked by high circulating glucocorticoids in face of low plasma adrenocorticotropic hormone (ACTH) (1). At the hypothalamic-pituitary level, ongoing stress-induced corticotropin-releasing hormone- (CRH) and arginine vasopressin- (AVP) driven expression of the ACTH-precursor POMC coincides with impaired proprotein convertase 1 (PC1/3)-mediated processing into ACTH, with ultimately leaching of unprocessed POMC into the circulation (2). Despite uncertainty...

ea0064012 | Evolution of Circulating Thyroid Hormone Levels in Preterm Infants during the First Week of Life: Perinatal Influences and Impact on Neurodevelopment | BES2019

Evolution of circulating thyroid hormone levels in preterm infants during the first week of life: Perinatal influences and impact on neurodevelopment

An Eerdekens , Gunnar Naulaers , Els Ortibus , Johan Verhaeghe , Lies Langouche , Christine Vanhole

Aim: For several decades, transient hypothyroxinemia of prematurity is topic of debate. The pathophysiology is incompletely understood and consensus on the therapeutic approach is lacking. This study aimed to obtain more insight in the pathogenesis by studying trends in thyroid hormone levels during the first week of life.Methods: This single-center prospective observational study studied plasma levels of total and free T4, total T3, TSH and TBG in cord ...

ea0041gp194 | Thyroid - Basic | ECE2016

Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study

Langouche Lies , Lehmphul Ina , Perre Sarah Vander , Kohrle Josef , Van den Berghe Greet

Introduction: Patients in need of an intensive care unit (ICU) treatment due to severe diseases often develop the non-thyroidal illness syndrome (NTI). These critically ill patients present with low thyroxine (T4), low 3,3’,5-triiodothyronine (T3) and elevated reverse T3 (rT3) serum concentrations while TSH and 3,3’-diiodothyronine (3,3’-T2) concentrations remain unaffected. To further elucidate the underlying changes ...

ea0057019 | Adrenocortical function during prolonged critical illness and beyond: a prospective observational study | BES2018

Adrenocortical function during prolonged critical illness and beyond: a prospective observational study

Bram Peeters , Philippe Meersseman , Sarah Vander Perre , Pieter J Wouters , Dimitri Vanmarcke , Yves Debaveye , Jaak Billen , Pieter Vermeersch , Lies Langouche , Greet Van den Berghe

Aim of the work: The time courses of ACTH, (free) cortisol and cortisol metabolites beyond the first week of critical illness and upon recovery have not been documented. We studied adrenocortical function over time in relation to critical illness duration and presence of sepsis/septic shock, to initiation of glucocorticoid treatment, and to recovery/death.Methods: Patients still in ICU on day 7 (N=392) and 20 matched healthy subjects were includ...

ea0097001 | Section | BES2023

Hydrocortisone treatment increases cholesterol availability in prolonged septic mice: effect on adrenal and muscle functioning

Bruyn Lauren De , Arno Teblick , Oudenhove Tim Van , Perre Sarah Vander , Inge Derese , Lies Pauwels , Sarah Derde , Berghe Greet Van den , Lies Langouche

Background: Sepsis is hallmarked by an immediate and sustained decrease in total-, HDL-, and LDL- cholesterol, associated with poor outcome and suggested to be a potential contributor to adrenal failure and muscle weakness in the critically ill. Although the underlying mechanisms are unclear, this sepsis-induced hypocholesterolemia has been postulated to be due to an increased conversion of cholesterol to cortisol. We hypothesized that hydrocortisone (HC) trea...