Searchable abstracts of presentations at key conferences in endocrinology

ea0014p162 | (1) | ECE2007

Segregation of P25L and S80I mutations of the vhl gene in an extended Hungarian family with von Hippel-Lindau syndrome

Patócs Attila , Balogh Katalin , Tóth Miklós , Fazakas Ferenc , Likó István , Rácz Károly

Background: von Hippel-Lindau syndrome (VHL) is a rare autosomal dominant disease caused by alterations of the vhl tumor-suppressor gene. Patients with VHL are at risk for development of retinal, central nervous system and spine hemangioblastomas, clear-cell renal cell carcinomas, pheochromocytomas, endolymphatic sac tumors and cysts; and pancreatic islet cell tumors. Based on the presence or absence of pheochromocytoma as a phenotypic marker, VHL can be divided into di...

ea0040p6 | (1) | ESEBEC2016

Toxicity of tyrosine kinase inhibitors in the treatment of thyroid cancer – a 10-year experience resume

Krajewska Jolanta , Kukulska Aleksandra , Paliczka-Cieślik Ewa , Handkiewicz-Junak Daria , Gawlik Tomasz , Olczyk Tomasz , Kropińska Aleksandra , Michalik Barbara , Gubała Elżbieta , Jarząb Barbara

Targeted therapy based on tyrosine kinase inhibitors (TKIs) constitutes a new treatment modality in thyroid cancer (TC). Their efficacy in prolongation of progression free survival in comparison to placebo has been documented in phase III studies. However, a problem of their tolerability has recently risen as numerous side effects influencing the quality of life may potentially limit their clinical use. Therefore, we decided to carry out a retrospective analysis of the frequen...