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ea0031oc1.8 | Young Endocrinologists prize session | SFEBES2013

Kisspeptin advances ovulation in healthy women

Comninos Alexander , Jayasena Channa , Nijher Monica , Abbara Ali , De Silva Akila , Veldhuis Johannes , Ratnasabapathy Risheka , Izzi-Engbeaya Chioma , Lim Adrian , Patel Daksha , Ghatei Mohammad , Bloom Steve , Dhillo Waljit

Background: The KISS1 gene, is a critical regulator of normal reproductive function. In humans, KISS1 deletion results in a failure to go through puberty while activating mutations result in central precocious puberty. Administration of kisspeptin induces ovulation in rodents and sheep. However chronic exposure to exogenous kisspeptin-54 leads to profound tachyphylaxis in women with hypothalamic amenorrhoea. It is not known whether exogenous kisspeptin can alter the m...

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ea0021p328 | Reproduction | SFEBES2009

Twice-weekly administration of kisspeptin leads to long-term stimulation of reproductive hormone release in infertile women with hypothalamic amenorrhoea

Jayasena Channa N , Nijher Gurjinder M K , Abbara Ali , Murphy Kevin G , Lim Adrian , Patel Daksha , Mehta Amrish , Todd Catriona , Ramachandran Radha , Donaldson Mandy , Trew Geoffrey , Ghatei Mohammad A , Bloom Stephen R , Dhillo Waljit S

Background: Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. We have recently shown that a single injection of the novel hormone kisspeptin potently stimulates reproductive hormone release in women with HA. However, twice-daily kisspeptin administration to women with HA, results in tachyphylaxis due to desensitisation of the kisspeptin receptor. This suggest...

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Endocrine Abstracts

Kisspeptin advances ovulation in healthy women

Twice-weekly administration of kisspeptin leads to long-term stimulation of reproductive hormone release in infertile women with hypothalamic amenorrhoea

BiosciAbstracts