ea0020p536 | Growth and Developmental Endocrinology | ECE2009
, Devany Emral
, Lima Giovanna
, Bidlingmaier Martin
, Strasburger Charistian
The physiological and pathophysiological significance of hGH isoforms remains to be fully elucidated. In order to study the two most abundant hGH isoforms 20 and 22 kDa hGH, we have generated monoclonal antibodies (mAbs) against 20 and 22 kDa hGH. The mAbs against 20 and 22 kDa were characterized for their specificity and epitopes with different binding assays as well as by Western blot. The mAb 1G12 against 20 kDa with lower than 0.05% cross reactivity to 22 kDa hGH combined ...