Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1013 | Thyroid (non-cancer) | ECE2014

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women.

Vitkova Hana , Jiskra Jan , Springer Drahomira , Limanova Zdenka , Telicka Zdenek , Bartakova Jana , Potlukova Eliska

Introduction: Anti-C1q antibodies have been implicated in the pathogenesis of systemic lupus erythematosus. We have previously shown that anti-C1q antibodies are also linked to autoimmune thyroid disorders (AITD). The aim of this study was to assess the occurrence of anti-C1q antibodies in pregnant women with AITD.Methods: Serum anti-C1q antibodies were measured during the 9–11th gestational weeks in 103 pregnant women screened positive for AITD, an...

ea0032p1011 | Thyroid (non-cancer) | ECE2013

Latent toxoplasmosis: a novel risk factor for autoimmune thyroid diseases in pregnancy?

Potlukova Eliska , Prochazkova Lucie , Jiskra Jan , Limanova Zdenka , Springer Drahomira , Calda Pavel , Flegr Jaroslav , Kankova Sarka

Introduction: Latent toxoplasmosis, a zoonosis caused by protozoan Toxoplasma gondii, is the most widespread human parasitosis in developed countries (prevalence 20–80%). Upon infection, T. gondii stays in human organism lifelong. It has been linked to several autoimmune diseases, including autoimmune thyroid disease (AITD). The aim of our study was to assess the impact of latent T. gondii infection on the prevalence of AITD in pregnancy with re...

ea0032p1012 | Thyroid (non-cancer) | ECE2013

Iodine status in women after early miscarriages in the Czech Republic

Jiskra Jan , Fait Tomas , Bilek Radovan , Bartakova Jana , Potlukova Eliska , Springer Drahomira , Telicka Zdenek , Limanova Zdenka

Background: Early miscarriages are of multifactorial origin. Subclinical thyroid dysfunction belongs to the common causes. Thyroid dysfunction in pregnancy is caused mainly by thyroid autoimmunity and/or iodine deficiency. The Czech Republic belongs to countries with sufficient iodine intake. The aim of the study was to determine iodine status in women after early miscarriages (n=183) and to compare it with randomly chosen age-comparable euthyroid women without previo...

ea0022p787 | Thyroid | ECE2010

Serum levels of antibodies to thyroid peroxidase in women after miscarriages in comparison with the 1st trimester of pregnancy and healthy non-pregnant women

Jiskra Jan , Fait Tomas , Limanova Zdenka , Antosova Marie , Telicka Zdenek , Springer Drahomira , Potlukova Eliska

Background: Etiology of infertility and miscarriages is multifactorial. Negative impact of overt thyroid dysfunction on fertility, pregnancy and development of offspring is known. Moreover, even presence of euthyroid autoimmune thyroid diseases may increase risk of miscarriages. The prevalence of positive antibodies to thyroid peroxidase (TPOAb) ranges 9–39% in women with recurrent miscarriages and 0–37% in controls. The aim of the study was to compare serum concentr...

ea0014p304 | (1) | ECE2007

The prevalence of anti-C1q antibodies is increased in autoimmune thyroid disorders

Potlukova Eliska , Jiskra Jan , Sandova Petra , Limanova Zdenka , Smutek Daniel , Mareckova Helena , Antosova Marie , Trendelenburg Marten

Background: Autoantibodies directed against complement C1q (anti-C1q) have been described in a number of systemic autoimmune disorders. In systemic lupus erythematosus, they are strongly associated with proliferative lupus nephritis. However, no study has focused on the presence of anti-C1q in organ specific autoimmune disorders. The aim of this study was to determine the prevalence of anti-C1q in autoimmune thyroid disorders (AITD).Methods: Serum levels...

ea0022p808 | Thyroid | ECE2010

Thyroid hormones regulate the production of complement mannan-binding lectin regardless of the MBL2 genotype: a cohort study of 95 patients with autoimmune thyroid disorders.

Potlukova Eliska , Jiskra Jan , Freiberger Tomas , Limanova Zdenka , Zivorova Dana , Malickova Karin , Springer Drahomira , Grodecka Lucie , Antosova Marie , Telicka Zdenek , Pesickova Sattu Sinikka , Trendelenburg Marten

Introduction: Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD).Methods: Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto...