Searchable abstracts of presentations at key conferences in endocrinology

ea0034p65 | Clinical practice/governance and case reports | SFEBES2014

Spontaneous hypoglycaemia in a non-diabetic patient with insulin antibodies

Graham Una , McQuillan Laura , Lindsay John

A 58-year-old non-diabetic Caucasian man was admitted with a capillary glucose of 1.9 mmol/l following an episode of confusion and disorientation. During his admission he had frequent episodes of nocturnal and early morning hypoglycaemia with capillary glucose <3.0 mmol/l. After 21 h of supervised fasting he was symptomatic with plasma glucose 2.3 mmol/l, insulin >1000 mU/l and C-peptide 19.6 μg/l. Sulphonylurea screen was negative. Given the magnitude of serum in...

ea0015p1 | Bone | SFEBES2008

Presentation of primary hypoparathyroidism during pregnancy: maternal and fetal effects

Lindsay John , Brown Dessie , O'Kane Maurice

Introduction: Newly diagnosed primary hypoparathyroidism during pregnancy has been reported rarely. We recently encountered a first presentation of maternal hypoparathyroidism that was complicated by acute maternal and fetal hypocalcaemia.Clinical presentation: A 36-year-old lady presented with hypocalcaemia at delivery of her third child. While early antenatal progress was uncomplicated she was admitted at 36 weeks gestation with pre-eclampsia and supra...

ea0044p60 | Bone and Calcium | SFEBES2016

Would a 10% fracture risk threshold for direct access to dual energy densitometry (DXA) exclude patients with low bone mineral density?

Wilson Clare , Loughrey Paul , Cummings Bernie , McNally Colette , Lindsay John

The SIGN guideline group recently suggested a fracture risk threshold of 10% as an indication for DXA. Patients who do not have a 10 year fracture probability of 10% or more would therefore not meet the criteria for direct access to DXA. In order to assess whether implementing these guidelines would impact overall management, we undertook a prospective audit of our direct access DXA and health promotion service. Charts from 61 consecutive patients were reviewed (54F/7M, Mean a...

ea0037ep481 | Diabetes (complications &amp; therapy) | ECE2015

Initial experience of SGLT2 inhibitor use in type 2 diabetes

Cooke Barbara , Ryan Kathryn , Gormley Mark , Lindsay John

Introduction: SGLT2 inhibitors offer a novel approach to improve glycaemic control in patients with type 2 diabetes through inhibition of renal glucose reabsorption. Phase 3 clinical trials demonstrated consistent glucose lowering effects and weight loss. The objective of our audit was to assess the early effects of treatment with dapagliflozin 10 mg in our clinic population.Methods: We performed a retrospective audit of clinical parameters in patients (...

ea0028p373 | Thyroid | SFEBES2012

Testicular choriocarcinoma: a rare case of thyrotoxicosis arising as a paraneoplastic syndrome

McCracken Emma , Johnston Philip , Lindsay John , Black Neil

An 18 year old male presented with dyspnoea, haemoptysis, weight loss and a large right testicular swelling. On examination he appeared cachectic, diaphoretic and tachycardic. A large firm non-fluctuant right-sided scrotal swelling was present. There were no signs of goitre or dysthyroid eye disease. Thyroid function tests revealed biochemical hyperthyroidism: [fT4 38.6 pmol/L (NR: 9.4–18.6), TSH <0.01 mu/L (NR: 0.3–4.4)]. CT chest demonstrated multiple large pul...

ea0015p85 | Clinical practice/governance and case reports | SFEBES2008

Challenges in management of primary hypoparathyroidism associated with autoimmune polyglandular syndrome type 1 (APS I)

Wallace Ian , McConnell Vivienne , Bell Patrick , Lindsay John

APS I is a rare condition with autosomal recessive inheritance. We report a series of three sisters (Table 1), affected by APS I, who all had a mutation of the autoimmune regulator (AIRE) gene. An index case (A) died at 26 years old due to vascular complications.The management of primary hypoparathyroidism in case A, who also had type I diabetes was also complicated by nephrocalcinosis, renal calculi, chronic renal failure and vascular calcification. In ...