Endocrine Abstracts

Introduction: The mean time from onset of symptoms to diagnosis in NEN is around 5-7 years. Late stage NEN is often diagnosed during an emergency admission. The difference in overall survival (OS) between emergency and elective diagnoses has not been studied. This study assesses factors associated with emergency presentation (EP) versus routine presentation (RP), evaluates factors associated with late presentation, and correlates these with OS. Methods: ...

Introduction: European Neuroendocrine Tumour Society guidelines advocate the use of platinum-based chemotherapy in combination with Etoposide as first line chemotherapy in advanced GEP-NEC. Following this regime, 30% of digestive NEC and 60% of colorectal NEC showed a lack of benefit or evidence of disease progression. Available retrospective evidence is from small studies. Other studies have shown BMI relates to survival in NEN. This study aims at studying chemotherapy regime...