Endocrine Abstracts

The simultaneous occurrence of MTC and extrathyroidal B large cell NHL are very rare. MTC may be sporadic or part of a MEN and NHL is not reported in association with MEN. A woman of 76 year old with a history of cholelithiasis and hepatitis B, is admitted for left abdominal pain. On examination it is detected inguinal, axillary and clavicular lymphadenopathy, splenomegaly and also a multinodular thyroid disease. The thyroid function was normal, antithyroid antibodies were neg...

Long-standing primary failure of pituitary-dependent endocrine glands may induce pituitary hyperplasia and adenoma both related to duration and severity of peripheral gland insufficiency, although the formation of an adenoma is rare. We report the case of an elderly man with pituitary macroadenoma but compensated adrenocortical failure. A 70-year-old man referred our centre in 2013 for headache and horizontal diplopia. MRI revealed pituitary macroadenoma (1.9×1.1×2.2...

The high morbidity and mortality rate of women with Turner syndrome (TS) is primarily a results of the cardiovascular complications and so it is necessary an accurate and precocious diagnosis of this disease. Congenital cardiac anomalies, whose causes remains unknown, are common in TS (21–40%), in particular among patients with 45 X; between these the ventricular septal defect (VSD) is very rare (in a recent review, 3/1092 cases) (Gravholt 2004) and so in neonatal with VS...

The association of immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) are widely and to with good effect used in the treatment of many neoplasms. Much evidence of endocrine side effects has been reported for both ICIs and TKIs especially to the pituitary and thyroid functions; however, there are few records of primary adrenal insufficiency. We report the case of a 44-year-old soldier, examined for elevated hematocrit findings. Abdominal ultrasound and th...

Pheochromocytoma is a rare neuroendocrine tumor; many cases are sporadic but 1/3 are familial or syndromic and associated with many susceptibility genes including germline mutations of the gene encoding succinate dehydrogenase (SDH) subunits. We describe the case of a 70-years-old woman with arterial hypertension poorly controlled by therapy in a patient with secondary progressive multiple sclerosis started at 25 years of age, associated with euthyroid autoimmune thyroiditis, ...

Resistance to thyroid hormone (RTH) is a rare dominantly inherited condition of impaired tissue responsiveness to thyroid hormones. Different tissue may exhibit variable degree of resistance and clinical presentation probably depending on the heterogeneity of factors that modulate the isoform of thyroid hormone receptor (THR). The heart shows different isoforms of THR and few data is reported on the cardiac functionally effects of the phenotypic heterogeneity; echocardiography...

An adrenal incidentaloma >4 cm of size is considered suspected of malignancy and therefore often sent to the adrenalectomy for pathological verification. In these cases, in recent studies the role of 18F-FDG-PET / TAC has been evaluated. We report a case of 67 years old man hospitalized for abdominal pain, fever and oliguria in obese patient with a history of diabetes mellitus 2, chronic renal failure, arterial hypertension and subjected to PTCA about 10 years earlier for ...

Objective: decreased survival and higher cardiovascular risk have been reported in a UK cohort of RTHβ patients, but there is no evidence from other countries.Methods: retrospective study of an Italian cohort of RTHβ patients, carrying heterozygous pathogenic variants in the THRB gene and diagnosed in the period between 1984 and 2023. We collected records at diagnosis of 284 cases, whereas longitudinal data were available in 249 RTH&#9...