Searchable abstracts of presentations at key conferences in endocrinology

ea0013p234 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Effects of neurotensin and/or morphine on gene expression of mu and delta opioid receptor

Bai Bo , Liu Haiqing , Liu Yuhong

In the central nervous system, the opioid and non-opioid transmitter system jointly compete with multiple pathophysiological processes. The in vitro neuronal model of rat (Wistar) caudate putamen and reverse transcription-poly-merase chain reaction were used to examine the effects of neurotensin and/or morphine on the expression of mu or delt-opioid receptor mRNA. In the present study neurotensin (10 nmol/l) promoted but morphine (0.001 mmol/l) reduced mu or delt-opioid...

ea0077lb44 | Late Breaking | SFEBES2021

Depression and islet function during pregnancy: Generation of a depressive phenotype using UCMS

Smith Lorna , Fernandes Cathy , Simpson Sian , Liu Bo , Jones Peter , Bowe James

Gestational diabetes (GDM) occurs when beta-cell insulin secretory capacity is insufficient to meet the increased demands required to maintain normoglycemia during pregnancy. Considerable clinical evidence supports a link between depression and GDM, although underlying mechanisms are unclear. We used the unpredictable chronic mild stress (UCMS) rodent model of depression to examine the metabolic effects of depression in pregnant mice. C57BL/6J females were divided at 4-weeks-o...

ea0028p178 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Ablation of Peptide YY cells in adult mice reveals a role in beta-cell maintenance

Sam Amir , King Aileen , Hostomska Klara , Persaud Shanta , Liu Bo , Ghatei Mohammad , Bloom Stephen , Bewick Gavin

In the pancreas, PYY is expressed in a subpopulation of non-beta cells in the islets of Langerhans. The role of PYY-expressing cells in the adult pancreas is unknown. We generated a mouse model in which administration of diphtheria toxin (DT) produced specific ablation of PYY-expressing cells in the colon, pancreas and brainstem. Interestingly, DT administration to adult mice resulted in severe hyperglycaemia associated with significant loss of pancreatic insulin and disrupted...