Searchable abstracts of presentations at key conferences in endocrinology

ea0081p232 | Thyroid | ECE2022

Levothyroxine Replacement Therapy overuse. Factors suggesting treatment discontinuation

Livadas Sarantis , Bothou Christina , Paparodis Rodis , Androulakis Ioannis , Angelopoulos Nicholas , Boniakos Anastasios , Anagnostis Panagiotis , Duntas Leonidas

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

ea0049oc4.5 | Thyroid Disease 1 | ECE2017

Levothyroxine replacement therapy: once treatment is started, should it last indefinitely?

Livadas Sarantis , Bothou Christina , Androulakis Ioannis , Boniakos Anastasios , Angelopoulos Nicholas , Duntas Leonidas

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

ea0037ep616 | Obesity and cardiovascular endocrinology | ECE2015

A low glycaemic index, low glycaemic load snack based on stevia and fortified with vitamin D, improves metabolic/hormonal profile, and compliance in normal subjects and prediabetics; results from a 4 months, controlled trial

Livadas Sarantis , Dastamani Antonia , Stefanaki Charikleia , Mantzou Emily , Painesi Areti , Papanikolaou Eleni , Chrousos George

Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic and insulinotropic activities. Furthermore, Vitamin D deficiency may affect diabetes development in the long run.<p class="abst...

ea0032p610 | Female reproduction | ECE2013

Association of advanced glycosylation end products receptor polymorphisms with coronary heart disease in postmenopausal women

Xyrafis Xenofon , Toutouzas Konstantinos , Livadas Sarantis , Karachalios Athanasios , Stefanadis Christodoulos , Georgopoulos Neoklis , Diamanti-Kandarakis Evanthia

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

ea0022p481 | Female reproduction | ECE2010

Serum concentrations of carboxylated osteocalcin are increased and associated with the components of the polycystic ovarian syndrome

Diamanti-Kandarakis Evanthia , Livadas Sarantis , Katsikis Ilias , Piperi Christine , Mantziou Aimilia , Papavassiliou Athanasios G , Panidis Dimitrios

Objective: Intriguing studies suggest that osteocalcin (OC) and its carboxylated (Gla)/uncarboxylated form are involved in the regulation of insulin secretion and action. Additionally, advanced glycated end products (AGEs), directly regulate the secretion of these osteoblast derived molecules. In PCOS among the pathophysiological aberrations, deregulation of insulin secretion and action as well as elevated AGEs levels have been demonstrated. In this study, we evaluated the ser...

ea0020p633 | Reproduction | ECE2009

Advanced glycosylated end products are associated with anovulatory markers in women with polycystic ovary syndrome

Diamanti-Kandarakis Evanthia , Piouka Athanasia , Livadas Sarantis , Piperi Christine , Katsikis Ilias , Papavasiliou Athanasios , Panidis Dimitrios

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

ea0016p641 | Reproduction | ECE2008

Serum concentrations of atherogenic proteins Neutrophil gelatinase-associated lipocalin and its complex with Matrix Metaloproteinase-9 are significantly lower in women with Polycystic Ovary Syndrome: hint of a protective mechanism?

Diamanti-Kandarakis Evanthia , Livadas Sarantis , Kandarakis Stylianos , Margeli Alexandra , Papassotiriou Ioannis

Background: Neutrophil gelatinase-associated lipocalin (NGAL) and the Matrix Metaloproteinase-9 (MMP-9) have been considered as important mediators of vascular remodeling and plaque instability. The formation of a complex with NGAL and MMP-9 is crucial for atherotic plaque erosion and thrombus formation. In women with Polycystic Ovary Syndrome (PCOS) the incidence of cardiovascular clinical events is not increased, despite the fact that they display a wide spectrum of risk fac...

ea0056p918 | Female Reproduction | ECE2018

Young lean women with evidence of both premature adrenarche and pubarche display a metabolic, hormonal and psychologic profile that is similar to that of their peers with polycystic ovary syndrome

Livadas Sarantis , Bothou Christina , Kanaka-Gantenbein Christina , Chiotis Dimitrios , Angelopoulos Nicholas , Macut Djuro , Chrousos George P.

Context: The early activation of adrenal zona reticularis, denoted by increased circulating levels of adrenal androgens before the age of eight years in girls is called premature adrenarche (PA), while the concomitant appearance of pubic hair is termed premature pubarche (PP). Girls with PA-PP display an unfavorable metabolic, hormonal and psychologic profile, compared to their normal peers and are also at an increased risk of developing polycystic ovary syndrome (PCO...

ea0073aep225 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The effect of obesity on the association between type 2 diabetes mellitus and polycystic ovary syndrome: a meta-analysis of observational studies

Anagnostis Panagiotis , Paparodis Rodis , Bosdou Julia , Bothou Christina , Macut Djuro P. , Goulis Dimitrios , Livadas Sarantis

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

ea0084op-06-30 | Oral Session 6: Hypothyroidism | ETA2022

Levothyroxine replacement therapy overuse and factors guiding successful treatment discontinuation: short and long-term observation data of a large cohort

Livadas Sarantis , Androulakis Ioannis , Angelopoulos Nikolaos , Anagnostis Panagiotis , Paparodis Rodis , Boniakos Anastasios , Askitis Dimitrios , Duntas Leonidas

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01&pm;15.96 (range 17-84years) with 8.59&pm;6.98 years on LT4Rx witho...