Endocrine Abstracts

Background: Several treatment options exist after thyroid malignancy has been ruled out in patients with multinodular goiter (MG). Surgery efficiently reduces the goiter size but carries a risk of both surgical and anesthetic complications while in recent years, levothyroxine suppressive therapy has been abounded. I131 therapy is the only nonsurgical alternative; however, the effectiveness diminishes with increasing goiter size and depends on iodine sufficiency in some areas. ...

Introduction: Conventional treatment of secondary hyperparathyroidism (SHP) requires supplementation of vitamin d analogues combined with calcium however several studies have reported concerns regarding the safety of calcium supplements particularly in the long term. If vitamin d without concomitant calcium supplementation is sufficient to prompt a fall in the parathyroid hormone (PTH) is still not known with certainty. The purpose of our study was to investigate if vitamin d ...

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

Background: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin–containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alteration...

Introduction: Thyroglossal duct (TGD) carcinoma is an uncommon entity, diagnosed in patients undergoing evaluation of the neck for midline swelling, or incidentally after removal of a TGD cyst. Despite the presence of multiple publications on the topic, no systematic characterization of these tumors has been performed to date.Methods: We performed a systematic search for the term “Thyroglossal duct” in Pubmed, Embase and Cochrane databases on D...

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic and insulinotropic activities. Furthermore, Vitamin D deficiency may affect diabetes development in the long run.<p class="abst...

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

Objective: Intriguing studies suggest that osteocalcin (OC) and its carboxylated (Gla)/uncarboxylated form are involved in the regulation of insulin secretion and action. Additionally, advanced glycated end products (AGEs), directly regulate the secretion of these osteoblast derived molecules. In PCOS among the pathophysiological aberrations, deregulation of insulin secretion and action as well as elevated AGEs levels have been demonstrated. In this study, we evaluated the ser...