Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep580 | Pituitary and Neuroendocrinology | ECE2020

Real life efficiency of pegvisomant therapy in acromegaly

Maria Lider Burciulescu Sofia , Livia Gheorghiu Monica , Caragheorgheopol Andra , Purice Mariana , Badiu Corin

Introduction: Pegvisomant (PEG) is an efficient treatment for acromegaly but the recommendation for this treatment is less active due to its high cost. In Romania it is reimbursed in doses up to 30 mg s.c/day or as 40 or 80 mg/week in combination with a somatostatin analog (SSA).Design: Retrospective analysis of 18 consecutive patients treated with PEG for acromegaly (either as monotherapy, or in combination with SSA and/or cabergoline (CAB...

ea0070aep1010 | Hot topics (including COVID-19) | ECE2020

Clinical presentation variations of pheochromocytomas

Maria Lider Burciulescu Sofia , Livia Gheorghiu Monica , Bojoga Andreea , Badiu Corin

Introduction: Pheochromocytoma (PCC) has a wide spectrum of clinical manifestations, from insidious disease to extreme symptoms. Various mechanisms of catecholamine and other mediators actions were related to the diversity of PCC presentation.Aim: We describe a retrospective study, of patients with PCC from a tertiary hospital, focusing on clinical and biochemical characteristics of PCC depending on means of discovery.Material and ...

ea0056p1159 | Thyroid cancer | ECE2018

Analysis of the prognostic factors during I-131 therapy for differentiated thyroid cancer patients using BIOMAT ENDO data base

Purice Mariana , Andreea Chiriac Iulia , Radulescu Monica , Livia Gheorghiu Monica , Goldstein Andrei-Liviu

BIOMAT-ENDO software is a Windows Forms application that stores all the main data regarding the patients with thyroid cancer (TC) hospitalized in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, starting with the first hospitalization, continuing with the periods of radioiodine therapy (RIT) and the follow up. Patient-monitoring MODULE contains clinical parameters, surgery details, in Vivo and in Vitro investig...

ea0073ep158 | Pituitary and Neuroendocrinology | ECE2021

Rapid decrease of a pituitary mass with gonadotrophic and thyrotrophic insufficiency – the case for lymphocytic hypophysitis?

Livia Gheorghiu Monica , Irina Andreea Bunea , Sofia Maria Lider Burciulescu , Anda Dumitrascu , Ramona Aldea

BackgroundLymphocytic hypophysitis is an unusual inflammation of the pituitary gland affecting mostly women. Its pathogenesis is still poorly understood and the presentation and clinical course vary largely. Serum prolactin levels may be low, normal, or elevated. Unlike what is observed in clinically nonfunctioning pituitary adenomas, there is not a clear hierarchy of anterior pituitary hormone deficiencies. Hypophysitismay resolve spontaneously, may rel...

ea0073ep197 | Thyroid | ECE2021

Transient thyrotoxicosis after laryngeal carcinoma surgery

Sofia Maria Lider Burciulescu , Costache Outas Mariana , Bunea Irina , Livia Gheorghiu Monica

IntroductionThyrotoxicosis debuted early after thyroid lobectomy is described in approximately 54% of cases. It has also been described in a few case reports after non thyroid neck surgeries or in invasive laryngeal cancer after total laryngectomy and debulking hemithyroidectomy.Case presentationPatient aged 53 years old, known with laryngeal carcinoma of 37/28/40 mm located at piriform sinus, linked by the l...

ea0086p100 | Neuroendocrinology and Pituitary | SFEBES2022

Adipose tissue and glycemic changes in patients with surgically treated acromegaly

Livia Gheorghiu Monica , Maria Prunariu Ana , Maria Lider Burciulescu Sofia , Purice Mariana , Iordachescu Carmen

Introduction: Excess GH in acromegaly has lipolytic action and detrimental effect on glucose metabolism and insulin signaling. Recent studies have suggested a specific lipodystrophy in patients with acromegaly. Paradoxically, although the visceral adipose tissue (VAT) and intrahepatic lipid were reduced in active acromegaly compared to controls, insulin resistance was increased. Fat was redistributed from subcutaneous and visceral depots to muscle; weight and VAT depots rose w...

ea0032p857 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Similar response to therapy of pituitary adenomas with and without SOX2-expressing cells

Coculescu Mihail , Campean Anca , Stancu Cristina , Capatina Cristina , Livia Gheorghiu Monica , Caragheorgheopol Andra , Hortopan Dan , Ciubotaru Vasile , Raica Marius

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...