Endocrine Abstracts

Introduction: Fine needle biopsy (FNB) is a very important diagnostic tool in the assessment of thyroid nodules and plays a prominent role in therapeutic approach. It has a sensitivity around 83 to 85% and a specificity around 80 to 92%.Aims: To correlate cytological (FNB) and final histopathological data in patients with nodular thyroid pathology.Methods: A retrospective study of patients who underwent surgical procedure from Janu...

Differentiated carcinoma of the thyroid (DCT) of follicular origin is the most frequent endocrine neoplasia and it usually has a good prognosis even in the disseminated disease, due to its slow growing pattern and low dissemination rate. The prevalence of metastasis described in the literature varies between 5 and more than 20%.Aims: To analyze the clinical–pathological data and their relation with survival of patients (pts) with metastatic DTC....

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers.Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTC).<p class="abstext"...