Searchable abstracts of presentations at key conferences in endocrinology

ea0090p585 | Calcium and Bone | ECE2023

Evidence of a non-classical phenotype of hypoparathyroidism in a cohort of adult patients with iron overload diseases

Evangelisti Selene , De Vincentis Sara , Rossi Barbara , Chiara Decaroli Maria , Locaso Michela , Ferrara Francesca , Rochira Vincenzo

Background: Iron overload disorders (IOD) are associated with a higher occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, including hypoparathyroidism (HPT). However, data about prevalence and presentation of HPT in this setting are scanty. A Ca/P ratio <2.32 has been proposed to detect HPT in the general population.Aim: To characterize Ca-P homeostasis, particularly the prevalence of HPT, in a cohort of adult patients with IOD compare...

ea0056p1051 | Thyroid (non-cancer) | ECE2018

Thyroid ultrasound alterations occurrence in patients with previous negative examination: A 6-years observational follow-up trial

Monzani Maria Laura , Brigante Giulia , Locaso Michela , Santi Daniele , Graziadei Luigi , Gnarini Valentina Luisa , Simoni Manuela , Madeo Bruno

Background: Thyroid nodules represent a common clinical finding and their prevalence is increasing worldwide. However, the most recent international guidelines do not give indications on the need to retest adults with previous negative neck ultrasound (US).Aim: To evaluate the incidence of thyroid US abnormalities in patients with previous negative thyroid US and identify patient’s characteristics able to predict the risk of developing thyroid disea...

ea0081oc11.1 | Oral Communications 11: Thyroid 2 | ECE2022

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Simoni Manuela , Rochira Vincenzo , Santi Daniele , Brigante Giulia

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This ”peripheral hypothyroidism” has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...