Searchable abstracts of presentations at key conferences in endocrinology

ea0056p19 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal insufficiency during prednisolone treatment in patients with polymyalgia rheumatica or giant cell arteritis – prevalence and clinical approach

Willemoes Borresen Stina , Laursen Toke , Jensen Bente , Hilsted Linda , Marie Bartels Else , Feldt-Rasmussen Ulla , Locht Henning

Introduction: Prednisolone is standard treatment of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), but many patients are reluctant to discontinue prednisolone treatment even after remission of the inflammatory conditions. Prednisolone-induced adrenal insufficiency can give manifest or latent symptoms, causing failure to taper and withdraw prednisolone. We therefore aimed to find the prevalence of adrenal insufficiency in prednisolone-treated patients with PMR/GCA...

ea0037ep46 | Adrenal cortex | ECE2015

Adrenal insufficiency during prednisolone treatment: need for cortisol replacement strategies in patients on long-term low-dose glucocorticoid treatment?

Borresen Stina Willemoes , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Background: Patients on long-term glucocorticoid treatment are at risk of adrenal insufficiency during glucocorticoid treatment. The side effect can occur during glucocorticoid treatment if there is a mismatch between glucocorticoid requirements and production/intake. High-dose glucocorticoid treatment is often sufficient to overcome most stressful situations. A low-dose of 5 mg prednisolone/day is however, equivalent to 20 mg hydrocortisone, a dose often used as basal glucoco...

ea0035p35 | Adrenal cortex | ECE2014

Glucocorticoid-induced adrenal insufficiency in prednisolone treated patients and how it relates to glucocorticoid dose and the duration of treatment

Dinsen Stina , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Feldt-Rasmussen Ulla

Objective: We aimed to assess the prevalence of glucocorticoid-induced adrenal insufficiency in prednisolone treated patients, and its relation to glucocorticoid dose and duration of treatment.Subjects and measures: As part of a larger study 48 patients with rheumatoid arthritis (33 women, aged 34–85 years) treated with a mean prednisolone dose of 7.0 mg (range 5–20 mg) per day, and a mean duration of treatment of 95 months (range: 6–360 m...

ea0081p517 | Adrenal and Cardiovascular Endocrinology | ECE2022

Impact of glucocorticoid-induced adrenal insufficiency on health-related quality of life

Willemoes Borresen Stina , Brun Boesen Victor , Watt Torquil , Bue Bjorner Jakob , Baslund Bo , Locht Henning , Bjork Thorgrimsen Toke , Jensen Bente , Sorensen Soren Schwartz , Lund Hetland Merete , Hansen Annette , Norregaard Jesper , Klose Marianne , Feldt-Rasmussen Ulla

Objective: Glucocorticoid-induced adrenal insufficiency is highly prevalent, but the clinical consequences are not fully understood. Therefore, the indication of adding stress dosages of glucocorticoid during ongoing anti-inflammatory glucocorticoid treatment remains unclear. The aim of this study was to determine the impact of adrenal function on health-related quality of life (HRQoL) in patients receiving ongoing low-dose prednisolone treatment.Methods...

ea0049ep40 | Adrenal cortex (to include Cushing's) | ECE2017

Predictive baseline morning P-cortisol levels for the response to a Synacthen test in prednisolone treated patients

Borresen Stina Willemoes , Klose Marianne , Locht Henning , Laursen Toke , Jensen Bente , Hilsted Linda , Baslund Bo , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Introduction: Evaluation of glucocorticoid production generally requires a dynamic test. Cut-off levels for baseline cortisol concentrations predicting the outcome of a Synacthen test have been proposed for different cortisol assays. With introduction of the new Roche Elecsys Cortisol II assay, P-cortisol concentrations are expected to decrease by 20%. We have investigated cut-off levels for baseline P-cortisol concentrations measured with the Roche Elecsys Cortisol II assay t...