Endocrine Abstracts

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP),...

Objective: To investigate the effect of BMI on the absolute change from baseline levels in circulating sex hormone in postmenopausal women treated with oral continuous combined low dose HT for 6 months.Design: The study recruited 36 postmenopausal women who received daily E2 1 mg/NETA 0.5 mg for 6 months. Hormonal assessment included measures of serum concentrations of FSH, LH, 17β-estradiol and free estrogen index (FEI), total and free testosterone...