Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep806 | Nuclear receptors and Signal transduction | ECE2017

3-Iodothyronamine induces transient receptor potential melastatin 8 (TRPM8) channel activation in human corneal endothelial cells and human corneal keratocytes

Ljubojevic Nina , Khajavi Noushafarin , Lohse Katharina , Valtink Monika , Mergler Stefan

3-Iodothyronamine (3-T1AM) is an endogenous metabolite of thyroid hormone (TH) for which was shown to have various effects. One of the effects is body temperature decline, which may be related with menthol receptor TRPM8. Normally, this ion channel is expressed in neuronal tissue, where it has a nociceptive role. Functional TRPM8 expression has also been shown in non-neuronal cells of the eye such as corneal and conjunctival epithelial cells, corneal endothelial cel...