Searchable abstracts of presentations at key conferences in endocrinology

ea0021p137 | Diabetes and metabolism | SFEBES2009

Salicylate induces insulin sensitivity by alleviating endoplasmic reticulum (ER) stress in cultured primary human adipocytes

Tripathi Gyanendra , Alhusaini Saif , McGee Kirsty , Lois Kostantinos , Harte Alison , McTernan Philip , Kumar Sudhesh

Background: Adipose tissue (AT) may have a significant role in obesity associated inflammation but, the mechanisms underlying the pathogenesis of obesity induced inflammation remains unclear. Recent murine studies indicate that ER stress is critical to the initiation and integration of inflammation and insulin signalling pathways. The ER stress occurs primarily due to accumulation of unfolded proteins and results in activation of the unfolded protein response to restore ER hom...