Endocrine Abstracts

MODY as a result of a genetic variant in the HNF1-α gene is traditionally treated with sulphonylureas, often with eventual progression to insulin use due to the loss of beta cell function. We present the case of a 58-year-old female who attended the diabetes service for many years for a genetically confirmed diagnosis of HNF1-α MODY. She was originally diagnosed with pre-diabetes at the age of 16 and eventually commenced on oral hypoglycaemic agents (OHAs) at the age...

Lactation is under the control of the anterior and posterior pituitary via prolactin and oxytocin release. A number of galactogogues, including dopamine antagonists, have been described and used with success in lactation induction. To date, there are no reports in the literature of their use in patients with panhypopituitarism. We present the case of a forty-year-old female known to endocrinology services with a background of anterior panhypopituitarism and AVP deficiency asso...

Paraganglioma is a rare neuroendocrine tumour. There are few case reports in the literature describing vaginal paraganglioma to date. We present the case of a 37-year-old female referred to endocrinology services with symptomatic hypertension, initially noted during her first pregnancy three years prior. This was on a background of a vaginal paraganglioma diagnosed in 2006 which was excised by gynaecology services without complication. Her first pregnancy in 2021 was notable f...

Background: The COVID-19 pandemic has adversely affected population mental health. In April 2021 we conducted an observational study which demonstrated disruption in women’s reproductive and mental health during the first year of the pandemic. Our objective therefore was to perform follow up studies in this cohort of women at 6-monthly intervals, to assess the longer term enduring impact of the pandemic on reproductive and mental health.Materials/Me...

Phaeochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumours, the majority of which secrete excess catecholamines resulting in significant hypertension and tachycardia. Pre-operative blood pressure control with alpha-adrenoceptor blockade is therefore implemented. The aim of the study was to assess the pre-, intra- and post-operative outcomes of patients undergoing outpatient alpha-blockade in our centre. A retrospective chart analysis was conducted on patients w...