Searchable abstracts of presentations at key conferences in endocrinology

ea0029p897 | Female Reproduction | ICEECE2012

Progesterone levels on the hCG day and outcomes IVF in women with polycystic ovary syndrome

Peng C. , Long X. , Lu G.

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormon...

ea0028p299 | Reproduction | SFEBES2012

Motility of bovine mixed and sex-sorted spermatozoa incubated in physiologically normal or high-glucose media

Long Sophie , Fisher Pat , Gardner David

Background: A moderately high fructose diet fed to rat dams shifts the secondary sex ratio in the litters towards males. These dams, as well as diabetic pregnant mice, have elevated plasma glucose. Hence, high uterine fluid glucose or a hormone that may mark high glucose, may result in preferential selection of Y-bearing sperm at the point of fertilisation through effects of glucose on sperm motility. In this study, we assessed sperm motility after incubation in media with/wit...

ea0065p10 | Adrenal and Cardiovascular | SFEBES2019

Thyroid hormone receptors in the mouse kidney in health and chronic kidney disease

Tasinato Elena , Boelaert Kristien , Long David , Vasilopoulou Elisavet

Introduction: Chronic kidney disease (CKD) is a devastating condition characterised by progressive loss of renal function that leads to end-stage renal disease. In patients with CKD there is increased prevalence of subclinical hypothyroidism. The importance of thyroid hormone (TH) action on kidney development, growth and physiology has been established, however the role of TH on kidney disease progression is not well understood.Aim: To assess the express...

ea0009p39 | Growth and development | BES2005

Expression of Somatostatin receptors in normal human kidney

Bhandari S , Zhong W , Long E , Atkin S

Background Somatostatin has many putative biological effects in the kidney such as influencing renal blood flow and urine volume, tubular transport and cell regulation. It exerts these effects via five identified G-protein linked receptors. However, only somatostatin receptor proteins 1 and 2A have been described in human kidney so far. In this study, we examined the distribution of somatostatin receptors (SSTRs) in normal human adult kidney. Methods Formalin fixed paraffin em...

ea0054p7 | (1) | NuclearReceptors2018

MIR-96 regulates retinoic acid receptor gamma cross-talk with the androgen receptor to drive aggressive prostate cancer

Long Mark D , Rosario Spencer , Sucheston-Campbell Lara E , Smiraglia Dominic J , Campbell Moray J

The retinoic acid receptor gamma (RARg, encoded by NR1B3/RARG) is significantly downregulated but not mutated in the MSKCC and PRAD prostate cancer (PCa) cohorts in the Cancer Genome Atlas (TCGA) data. We investigated the consequences of modifying RARg expression.Independent of ligand, stable RARg knockdown stimulated RWPE-1 and LNCaP cells proliferation, changed the cell cycle profile and significantly altered global gene expression patterns th...

ea0005p208 | Reproduction | BES2003

Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men

Ross R , Jabbar A , Jones H , Roberts B , Dunkley K , Long A , Levine H , Cullen D

Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men.RJM Ross, A Jabbar, H Jones, B Roberts, K Dunkley, A Long, H Levine, DR CullenObjectives: A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL1621). Design: The study was approved by The South Sheffield Ethics Committee. Twelve testosterone deficient males were treated with the buccal tablet...

ea0054is10 | (1) | NuclearReceptors2018

Modulating glucocorticoid receptor function in breast and prostate cancer

Tonsing-Carter E. , Long T. , West D.C. , Harkless R. , Dolcen D.N. , Hosfield D. , Greene G.L. , Szmulewitz R.Z. , Conzen S.D.

In normal physiology, glucocorticoid receptor (GR) activation regulates cell type-dependent genes whose products influence metabolism, inflammation, cell cycle and apoptosis/cell survival pathways. Synthetic GR agonists, or glucocorticoids (GCs), are often used to treat hematologic malignancies because of GR’s ability to induce proapoptotic gene expression, inhibit nuclear factor–κB, and induce cell cycle arrest. In contrast, recent examination of GR expression ...

ea0054oc2 | (1) | NuclearReceptors2018

Stage-specific and global functions of NCOR2 in prostate cancer progression

Long1 Mark D , Singh Prashant K , Llimos Gerard , Rosario Spencer , Smiraglia Dominic , Campbell Moray J

The corepressor NCOR2/SMRT regulates multiple nuclear receptors (NRs) and other transcription factors. Disruption to these functions are implicated in prostate cancer (PCa) progression but the details remain enigmatic. Therefore we sought to define the global functions of NCOR2/SMRT using isogenic PCa cell models, PCa mouse models and human PCa cohorts.We mapped the NCOR2 dependent transcriptome (RNA-seq), miRnome (miRNA-seq), methylome (EPIC methylation...

ea0037ep463 | Diabetes (complications & therapy) | ECE2015

Male patients benefit from initial exenatide treatment: a real-world experience

Chen Liang , Kuang Jian , Pei Jianhao , Chen Hongmei , Chen Zhong , Li Zhongwen , Yang Huazhang , Fu Xiaoyin , Wang Long , Chen Zhijiang

Objective: The purpose of this study was to describe the outcome after initiation of exenatide therapy and to determine whether the impact of adverse drug reactions on compliance was affected by gender.Methods: A retrospective study was performed of 18 diabetic patients (eight males) that were prescribed exenatide between June 2013 and September 2014. Each included patient received exenatide for ≥1 month. Age, disease course, race, BMI, medical his...

ea0037ep962 | Thyroid (non-cancer) | ECE2015

Lifestyle intervention reduces TPO antibody level in euthyroid patients: a retrospective cohort study

Chen Liang , Kuang Jian , Pei Jianhao , Chen Hongmei , Chen Zhong , Li Zhongwen , Yang Huazhang , Fu Xiaoyin , Wang Long , Chen Zhijiang

Objective: To investigate the impact of lifestyle intervention on elevated thyroid peroxidase (TPO) antibody levels in outpatients with normal thyroid function.Methods: A retrospective cohort study was performed to observe and evaluate euthyroid patients with excessive TPO antibodies that presented to the authors’ hospital between March 2013 and October 2014 for routine medical examinations. The subjects were randomly divided into the lifestyle inte...