Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1076 | Thyroid (non-cancer) | ECE2014

Therapeutic options for Grave's disease and toxic nodular disease: experience of an endocrinology department

Silva Joao , Marcelino Mafalda , Lopes Ana , Lopes Luis , Passos Dolores , Salgado Lucilia , Costa Paulo , Ferreira Bruno , Campos Pedro , Lopes Carlos , Castro Joao Jacome de

The thyroid pathology is an area of special interest in our department. Hyperthyroidism represents 3.4% of the 8144 patients followed.The aim of this study is to characterize the therapeutic approach in patients with Grave’s disease (GD) and toxic nodular disease (TND).Retrospective study of 217 patients diagnosed with GD and TND, evaluated according parameters of therapeutic option, efficacy, relapse rate and associated compl...

ea0016p96 | Bone and calcium | ECE2008

Effects on bone turnover and bone mineral density of levothyroxine suppressive therapy in patients with benign nodular goiter

Duarte Leone , Silva-Nunes Jose , Lopes Ana-Filipa , Malheiro Fernando

Introduction: Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is still a matter of debate.Objective: The aim of the present study was to assess the effects of levothyroxine treatment on bone mineral density (BMD) and biochemical bone turnover markers.Methods: We determined thyroid function – TSH and free T4 (FT4), r...

ea0056p259 | Calcium & Vitamin D metabolism | ECE2018

Primary hyperparathyroidism: a rare cause of hypertension?

Lopes Ana , Palma Isabel , Teixeira Sofia , Cardoso Helena

Backgroud: Primary hyperparathyroidism is the most common cause of hypercalcemia, which is associated with an increased frequency of hypertension. However, there are no data on the prevalence of primary hyperparathyroidism in patients who present with hypertension.Clinical case: We present the case of a 40-year-old woman with a history of hypertension for ten years. In 2017 she was referred for evaluation of hypercalcemia. The patient denied any symptoms...

ea0049ep824 | Steroid metabolism + action | ECE2017

Ritonavir induced Cushing’s Syndrome in a patient under inhaled corticosteroids

Pereira Teresa Alves , Furtado Ines , Lopes Ana M , Fonseca Liliana , Palma Isabel

Introduction: Cushing’s Syndrome secondary to inhaled or topic corticosteroids is very rare, although there are reports of a link to cytochrome inhibitors. Ritonavir, a protease inhibitor used for treatment in human immunodeficiency virus (HIV) infection, is a potent inhibitor of cytochrome P450 3A4.The case: A 41 years old man - with personal history of asthma, HIV infection diagnosed in 2002 and hepatitis C infection since 1999 – was sent to ...

ea0056p1112 | Thyroid (non-cancer) | ECE2018

Levothyroxine absorption test: a safe help for difficult cases

Lopes Ana , Teresa Pereira Maria , Lito Pedro , Freitas Claudia , Teixeira Sofia , Cardoso Helena

Levothyroxine (L-T4) is the mainstay of treatment of hypothyroidism. Marked elevation of thyrotropin (TSH) in patients on high replacement doses is rare and can result from malabsorption, drug interaction or poor compliance. The levothyroxine absorption test is required to distinguish these causes and has proved to be safe. This test measures the serum free thyroxine (FT4) response to 1 mg of oral L-T4 over 4–24 h.Clinical cases: Case no 1: A 28-yea...

ea0020p324 | Clinical case reports and clinical reports | ECE2009

Insulin autoimmune syndrome in a patient with type 2 diabetes: a case report

Duarte Leone , Silva-Nunes Jose , Peerally Zulmira , Gomes Lurdes , Rogado Maria-Cristina , Lopes Ana-Filipa , Raposo Joao-Filipe , Malheiro Fernando

Introduction: Insulin autoimmune syndrome (IAS) is a clinical condition characterized by the presence of autoantibodies to insulin or insulin receptors in patients not previously treated with insulin. This syndrome has been reported mainly in Asia, and it is a rare cause of hypoglycemia in Caucasians. So far there are no reports of IAS in patients with type 2 diabetes mellitus never treated with insulin.Case report: The authors describe a 59-year-old Cau...

ea0020p352 | Diabetes and Cardiovascular | ECE2009

Coronary heart disease risk reduction in obese patients submitted to adjustable gastric band

Duarte Leone , Silva-Nunes Jose , Lopes Ana-Filipa , Santos Cristina , Coutinho Jose-Mario , Botelho Maria-Manuel , Albuquerque Antonio , Malheiro Fernando

Background: Obesity is related to an increased cardiovascular risk, namely coronary heart disease risk (CHDr). Type 2 diabetes (T2D) is frequently associated with obesity and, by itself, is an important CHDr factor. Interventions that induce weight loss would be expected to attenuate CHDr in obese patients.Aims: To evaluate variation in cardiovascular risk profile one year after adjustable gastric banding (AGB), in obese patients (with and without T2D); ...

ea0056p719 | Clinical case reports - Pituitary/Adrenal | ECE2018

From adrenal incidentalomas to Cushing’s disease

Alves Pereira Teresa , Ferreira Lia , Furtado Ines , Lopes Ana , Fonseca Liliana , Amaral Claudia , Palma Isabel , Cardoso Helena

Introduction: Adrenal incidentalomas are asymptomatic adrenal masses found accidentally during routine examination, not intended for adrenal pathology evaluation. The functionality of these lesions must be further investigated. Rarely, bilateral adrenal nodular hyperplasia can be detected in a patient with Cushing’s disease. The authors present the case of a patient with possible autonomous cortisol secretion of adrenal origin that eventually emerged as Cushing’s dis...

ea0056ep15 | Adrenal and Neuroendocrine Tumours | ECE2018

IGF-2-oma: a diagnosis to be considered in a patient with a leiomyosarcoma and recurrent hypoglycemia

Fonseca Liliana , Ferreira Lia , Pereira Teresa Alves , Lopes Ana , Almeida Raquel , Vilaverde Joana , Pereira Maria Teresa , Cardoso Helena

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...

ea0049ep567 | Diabetes complications | ECE2017

Prevalence of distal symmetric polyneuropathy in diabetic patients in general medicine wards

Lopes Ana , Goncalves Helena , Fonseca Liliana , Branco Catarina Castelo , Goncalves Joao , Sousa Luisa , Calejo Margarida , Martins Sara , Neves Joao , Teixeira Sofia

Background: Distal symmetric polyneuropathy (DSPN) is one of the most prevalent chronic complications of diabetes and the most common cause in the pathway to diabetic foot ulceration. Screening for DSPN enables early intervention and prevention of complications. The Semmes-Weinstein Monofilament Examination (SWME) is currently the method of choice to screen DSPN, but ideally two neurologic tests should be used. The Michigan Neuropathy Screening Instrument (MNSI), which evaluat...