Searchable abstracts of presentations at key conferences in endocrinology

ea0026p626 | Clinical case reports | ECE2011

Virilizing ovarian steroid cell tumor: clinical case

Matos M J , Freitas P , Costa M A , Paiva V , Guimaraes M , Lopes J M , Carvalho D

Introduction: Androgen-producing tumors are a rare cause of hyperandrogenism (±0.2%). Ovarian steroid cell tumors represent <0.1% of all ovarian tumors. They may present at any age and in 12–50% of cases are associated with virilization. The majority of these tumors are benign or low-grade malignanies.Clinical case: A 74-year-old female patient, with history of vaginal hysterectomy for genital prolapse at the age of 50, is referred to Endoc...

ea0011p170 | Clinical case reports | ECE2006

Cushing’s syndrome due to medullary thyroid carcinoma – a case report

Sousa A , Rodrigues E , Varela A , Vinha E , Braga D , Couto P , Lopes J , Cardoso-Oliveira M , Medina JL

Ectopic ACTH secretion due to malignant tumours is a rare cause of hypercortisolism. Induced metabolic disturbances are often serious and the management of such patients may be difficult. We report the case of a 50-yr-old man who had a sporadic medullary thyroid carcinoma (MTC) removed 2 years ago (Dec/2003). Calcitonin and CEA levels remained high postoperatively and a CT scan revealed liver metastases. In August 2005 he was referred to Endocrinology with symptoms of muscular...

ea0002p82 | Signalling | SFE2001

A Threonine-Doublet within the Carboxyl-Terminal Tail of a Non-Mammalian Gonadotropin-Releasing Hormone Receptor is Critical for Rapid Agonist-Induced Internalization

Pawson A , Lopes J , Katz A , Maudsley S , Sellar R , Miller N , #Y-M|#Sun|# , Millar R , Davidson J

The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...

ea0029p799 | Endocrine tumours and neoplasia | ICEECE2012

Neuroendocrine Tumor with Clinical Characteristics of Insulinoma

Menezes J. , Rodrigues E. , Nogueira C. , Esteves C. , Jorge G. , Matos M. , Graca L. , Pinheiro J. , Pinheiro Loureiro , Lopes J. , Costa J. , Costa Maia , Carvalho D.

Introduction: Insulinomas are almost always located in the pancreas and are usually small. The peak incidence is from the third to fifth decade of life, with females being slightly more frequently affected. The average duration of neuroglycopenic symptoms prior to diagnosis is often prolonged, being more than 5 years in 20% of patients.Case presentation: Female, 52 years old, medical history notable for hypertension, dislipidemia and Graves disease. She ...