Searchable abstracts of presentations at key conferences in endocrinology

ea0026p740 | Diabetes (epidemiology, pathophysiology) | ECE2011

Comparison of the diagnostic criteria for PreDiabetes on a overweight population

Marcelino Mafalda , Chambel Paula , Paradinha Manuel , Domingues Andreia , Passos Dolores , Lopes Luis , Lopes Maria , Castro Joao

Introduction: ‘PreDiabetes’ was considered as a categories of increased risk for diabetes on the last ADA recommendations in 2010. The proposed diagnostic criteria include an HbA1c value between 5.7 and 6.4%, impaired fasting glucose (IFG) (100–125 mg/dl) and impaired glucose tolerance (IGT) levels (2-h values in the oral glucose tolerance test (OGTT) of 140 to 199 mg/dl). The HbA1c as new diagnostic criteria may actually increase the number of patients diagnose...

ea0032p396 | Diabetes | ECE2013

Quality of care in diabetic patients

Marcelino Mafalda , Domingues Andreia , Pereira Armando , Passos Dolores , Raimundo Joaquim , Silva Joao , Lopes Luis , Lopes Maria , Chambel Paula , Santos Valentim , de Castro Joao Jacome

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease, with prevalence increasing worldwide and its complications are major causes of early morbidity and mortality. Recent guidelines suggest the individualisation of glycaemic targets and glucose-lowering therapies.The aim of this study was to determine the quality of care provided to type 2 diabetic patients in our institution, analysing metabolic control, cardiovascular risk factors and pre...

ea0049ep139 | Clinical case reports - Pituitary/Adrenal | ECE2017

Gynecomastia in men: A rare case of adrenal feminizing tumors

Duarte Vitoria , Verissimo David , Passos Dolores , Serra Filipa , Silva Joao , Lopes Luis , Castro J.J. , Marcelino Mafalda

Estrogen-producing adrenal gland tumors (EPAGT) are extremely rare, accounting for only 1–2% of all adrenal tumors. They are most commonly observed in men or in children, and are unusual in women. They are almost always malignant even if they seem benign at presentation, and most of them have a poor prognosis. We present a case of a 71-year-old man with painful bilateral gynecomastia, without galactorrhea, over 4 months. Markedly elevated plasma estradiol levels were foun...

ea0041ep172 | Calcium and Vitamin D metabolism | ECE2016

Roux-en-Y Gastric Bypass reversal due to recalcitrant hypocalcaemia after total thyroidectomy

Silva Joao , Ivo Catarina , Simoes Helder , Lopes Luis , Passos Dolores , Marcelino Mafalda , de Castro Joao Jacome

Introduction: Hypocalcaemia is a potential post-thyroidectomy complication. Patients with previous Roux-en-Y Gastric Bypass (RYGBP) are at increased risk of symptomatic hypocalcaemia refractory to treatment. This complication is rare and there is not consensus on how to act.Clinic case: Female with 34 years old, with a history of Obesity (BMI 45.7 kg/m2), submitted to RYGBP in 2013, with a total loss of 47 kg (current BMI 27.3 kg/m2...

ea0041ep448 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Clinical inertia in type 2 diabetes mellitus without insulin treatment

Silva Joao , Ivo Catarina , Lopes Luis , Passos Dolores , Simoes Helder , Marcelino Mafalda , Jacome de Castro Joao

Introduction: Clinical inertia applied to type2 Diabetes Mellitus (T2DM) treatment, is defined as a lack of treatment’s intensification of patients who are not in HbA1c target. Clinical inertia leads to a postponement of new therapeutic introduction, with all complications associated with a poor metabolic control. In Portugal there are only studies that show good or poor metabolic control but do not mention clinician’s attitude towards these values. Recently publishe...

ea0041ep556 | Diabetes therapy | ECE2016

Effects of SGLT2 inhibitors in the treatment of a population with type 2 diabetes mellitus

Silva Joao , Ivo Catarina , Passos Dolores , Simoes Helder , Lopes Luis , Marcelino Mafalda , de Castro Joao Jacome

Introduction: The SGLT-2 inhibitors (InibSGLT2) are the newest class of non-insulin antidiabetic drugs (ANI) for type 2 diabetes mellitus (T2DM) treatment. Currently is only available in Portugal, dapagliflozin. This pharmacological class have shown benefits in metabolic control (reduction of 0.5–0.8% HbA1c) and in weight loss (1–3 kg).Objective: Evaluate the impact of InibSGLT2 in patients with T2DM followed in a Diabetes department.<p cla...

ea0037gp.25.04 | Thyroid – nodule | ECE2015

Evaluation of benign thyroid nodules in a 10-year follow-up

Silva Joao , Ivo Catarina , Marcelino Mafalda , Simoes Helder , Lopes Luis , Passos Dolores , de Castro Joao Jacome

Introduction: American Thyroid Association recommends that benign thyroid nodules should be revaluated 6–18 months after initial FNA and in case of stability the follow-up should be 3–5 years. However there isn’t any consensus about the periodicity of the follow-up.Aim: To evaluate the nodules in terms of function, size and malignancy in a 10-year follow-up.Methods: Retrospective study of 347 patients (543 benign thy...

ea0037ep299 | Calcium and Vitamin D metabolism | ECE2015

Parathyroid tissue in ectopic thyroid tissue

Silva Joao , Ivo Catarina , Marcelino Mafalda , Passos Dolores , Simoes Helder , Lopes Luis , de Castro Joao Jacome

Introduction: Postmortem studies have shown that a fifth parathyroid gland may be present in about 5% of patients with hyperparathyroidism. 1% of parathyroid glands are located in thyroid tissue. There’s a prevalence of 7–10% of thyroid ectopic tissue.Case report: A 53-year-old male, submitted to bilateral nephrectomy due to a Grawitz tumour at the age of 25. Under haemodialysis since then (with a rejected renal transplant in the past), he was ...

ea0037ep488 | Diabetes (complications &amp; therapy) | ECE2015

Hypoglycaemia due to drug interaction with clarithromycin

Silva Joao , Ivo Catarina , Marcelino Mafalda , Lopes Luis , Passos Dolores , Simoes Helder , de Castro Joao Jacome

Introduction: Interaction between diabetes mellitus (DM) and an infection usually results in hyperglycaemia. However, there is data describing hypoglycaemia events related with the association between certain antibiotics and oral anti-diabetic drugs or insulin.Case report: Male, 73 years old, with history of hypertension, obesity and dyslipidaemia. DM type 2 was diagnosed 13 years ago with any macro or microvascular complications so far. Currently he&#14...

ea0032p127 | Calcium and Vitamin D metabolism | ECE2013

Lithium-associated hyperparathyroidism: a case report

Marcelino Mafalda , Silva Joao , Lopes Luis , Salgado Lucilia , Lopes Carlos , de Castro Joao Jacome

Introduction: Lithium therapy is commonly used in bipolar disorder treatment. Alongside the increasing prevalence of goiter and hypothyroidism, the sustaining use of lithium therapy is associated with several metabolic disorders, such as hypercalcemia and hyperparathyroidism (HPT).Case report: A 64-year-old woman with history of bipolar disorder treated with lithium for several years was referred to our department for evaluation of recurrent hypercalcemi...