Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-04-31 | Thyroid Hormone Transporters and Development | ETA2022

The role of type 3 deiodinase in a human model for early brain development

Lopez Marti Anna , Gunhanlar Nilhan , Meima Marcel , Edward Visser W.

Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...

ea0084ps1-04-36 | Thyroid Hormone Transporters and Development | ETA2022

Thyroid hormone signaling in a human cellular model for early brain development

Gunhanlar Nilhan , Tellez Garcia Juan , Lopez Marti Anna , Shokrollahi Faezeh , Meima Marcel , Edward Visser W.

Background and Objective: Disrupted thyroid hormone (TH) signaling has devastating effects on human neurodevelopment. The molecular mechanisms underlying TH regulation and action are largely based on animal models. However, animal models are limited in revealing some of the most fundamental aspects of neurodevelopment that are unique to humans. We employed human induced pluripotent stem cell (iPSC) technology to study the effects of T3 on neurodevelopmental processes in a huma...

ea0101op-04-03 | Oral Session 4: Young Investigators/Basic | ETA2024

The role of type 3 deiodinase in a human model for early brain development

Lopez Marti Anna , Gunhanlar Nilhan , Sidal Gunduz Damla , Stavast Christiaan , Meima Marcel , Edward Visser W.

Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...