ea0084ps1-04-31 | Thyroid Hormone Transporters and Development | ETA2022
Lopez Marti Anna
, Gunhanlar Nilhan
, Meima Marcel
, Edward Visser W.
Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...