Endocrine Abstracts

Introduction: Childhood obesity is a severe public health concern. Various complications are recognised in adults, but the data remains limited in the paediatric population. Therefore, the aim of this study is to investigate the complications observed in children and young people (CYP) with obesity.Method: Retrospective data collection from 125 CYP aged between 0 and 18 years with a body mass index (BMI) standard deviation score (SDS) of two or more abov...

Introduction: Childhood obesity is associated with complications, such as type 2 diabetes mellitus (T2DM). The use of continuous glucose monitoring (CGM) in diabetes mellitus is well established, but there is limited research evaluating the role of CGM in childhood obesity. The aim of this study was to investigate the use of CGM in identifying glycaemic dysregulation in children and young people (CYP) with obesity and the effect of lifestyle therapy.<p cla...

Introduction: Raised intracranial pressure is a well-documented complication of obesity in the adult population, but this remains under-recognised in children and young people. The pathophysiology for this association remains unclear, but the complications of raised intracranial pressure can be devastating including potential visual loss. Therefore, the aim of our study was to investigate this link in children and young people.Method: Retrospective data ...

Introduction: Type 2 diabetes mellitus is a known complication of childhood obesity. It is currently diagnosed by undertaking an oral glucose tolerance test (OGTT). Continuous glucose monitoring (CGM) is used predominantly by patients with type 1 diabetes mellitus to monitor glucose levels.Aim: The aim of the study was to investigate glycaemic variation in children and adolescents with obesity who have had no evidence of pre-diabetes or type 2 diabetes o...

Introduction: Childhood obesity is associated with various complications and medical treatment options are limited. Liraglutide, a GLP-1 receptor agonist, has shown improvement in body mass index (BMI) in clinical trials and has been licensed for clinical use in adolescents >12 years of age. The aim of our study is to evaluate the effect of liraglutide treatment on cardiometabolic variables, quality-of-life (QoL) and satiety levels in adolescents with seve...

Introduction: Childhood obesity is associated with complications, such as impaired glucose tolerance and type 2 diabetes mellitus. The gold standard investigation for diagnosing glycaemic alterations is an oral glucose tolerance test (OGTT). Continuous glucose monitors (CGM) are routinely used in the management of children and young people (CYP) with type 1 diabetes mellitus. The aim of our study is to investigate whether CGM is more effective in identifying g...

Introduction: Socio-economic factors have a huge impact on children and young people’s (CYP) overall health status. The rates of childhood overweight and obesity continue to rise and the CYP from areas with higher social deprivation are adversely affected with higher rates of obesity. We report the link between socio-economic deprivation and complications from excess weight (CEW) in the CYP being managed in a tier 3 multi-disciplinary (MDT) weight managem...

Background: In type 1 diabetes (T1D), optimal glycaemic control requires intensive self-management to reduce the risk of complications. While routine downloading and review of blood glucose data is part of clinical practice of healthcare providers in an outpatient setting, patients and families are also educated, advised and encouraged to regularly download and review blood glucose data at home in order to make adjustments to insulin dosing for carbohydrate intake and insulin ...

Introduction: Obesity is a chronic and complex disease which is considered as one of the major health challenges with short- and long-term health consequences. Childhood obesity is defined as having a body mass index (BMI) at or above the 95th percentile for age and gender after two years of age. The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, is proven to promote weight reduction when used at a higher dose of 3.0 mg once daily. This study a...

Introduction: Children and adolescents with a body mass index (BMI) greater than the 98th centile are at an increased risk of complications including cardiovascular and liver disease and type 2 diabetes mellitus. Currently, lifestyle modification is the first line intervention. Pharmacotherapy, such as liraglutide and semaglutide, has recently been licensed for adolescents greater than 12 years of age. This study aimed to compare the impact of pharmacotherapy and lifestyle mod...