Searchable abstracts of presentations at key conferences in endocrinology

ea0041s9.1 | Bone marrow adipose tissue - A "novel" functionally active fat depot | ECE2016

Bone Marrow Adipose Tissue and bone, a bad romance

Lucas Stephanie

Bone Marrow Adipose Tissue (BMAT) has only recently become an emerging topic in both medical and basic research. As secretory cells found either packed or scattered within the BM, these adipocytes are likely contributors to haematopoiesis- or bone- related diseases. Indeed, clinical studies have consistently reported that BMAT amount is associated with bone loss in diverse types of osteoporosis such as that of ageing, post-menopause and anorexia nervosa. Since BM adipocytes an...

ea0050ep004 | Adrenal and Steroids | SFEBES2017

An unusual case of acute adrenal insufficiency

James Lucas , Bellankannan Raj , Buch Harit

Adrenal insufficiency is an uncommon endocrine condition with an incidence of 4 cases per million. Common non-iatrogenic causes include autoimmunity, infections and infiltrations. We describe a case of acute adrenal insufficiency secondary to an unusual cause.A 77-year old female was admitted under the surgeons with abdominal pain and pyrexia. Abdominal ultrasonography showed large stones within a thickened gallbladder and a pr...

ea0050ep004 | Adrenal and Steroids | SFEBES2017

An unusual case of acute adrenal insufficiency

James Lucas , Bellankannan Raj , Buch Harit

Adrenal insufficiency is an uncommon endocrine condition with an incidence of 4 cases per million. Common non-iatrogenic causes include autoimmunity, infections and infiltrations. We describe a case of acute adrenal insufficiency secondary to an unusual cause.A 77-year old female was admitted under the surgeons with abdominal pain and pyrexia. Abdominal ultrasonography showed large stones within a thickened gallbladder and a pr...

ea0038p94 | Clinical practice/governance and case reports | SFEBES2015

Do guidelines improve the diagnosis and investigation of hyponatraemia?

Broughton Chloe , Lucas Emily , Bhattacharya Beas

Introduction: Hyponatraemia is common and associated with significant morbidity and mortality. However, it’s often not recognised as a serious diagnosis and therefore inadequately investigated and poorly managed. An audit of the management of patients admitted to The Great Western Hospital (GWH) with hyponatraemia confirmed these problems. A hyponatraemia guideline was produced in order to improve diagnosis, investigation, and management of patients with hyponatraemia.</p...

ea0103oc10.3 | Endocrine Oral Communications 4 | BSPED2024

Increased prevalence of hypertension in paediatric turner syndrome

Sutherland Aimie , Lucas-Herald Angela , Mason Avril

Introduction: Turner syndrome (TS) is a chromosomal disorder characterised by an abnormality of or a partial or complete absence of one of the X chromosomes in a phenotypic female. The TS population experience aortic dissection at a rate ten times that of the general population, for which hypertension is a modifiable risk factor. Our primary aim was to determine the frequency of hypertension in girls attending a tertiary paediatric dedicated TS clinic in the West of Scotland a...

ea0063p333 | Reproductive Endocrinology 1 | ECE2019

Modes and actions of inter-individual transfer of estradiol and progesterone among conspecifics in both mice and bats

deCatanzaro Denys , Pollock Tyler , Greville Lucas , Faure Paul

We have investigated inter-individual transfer of 17β-estradiol (E2) and progesterone (P-4), and related it to mammalian ‘pheromonal’ effects. Assays of unconjugated E2 and P4 revealed their presence in male and female urine of laboratory mice and big brown bats (Eptesicus fuscus), which are phylogenetically very distant from each other. These small and lipophilic steroids readily pass through biological membr...

ea0094oc6.5 | Metabolism, Obesity and Diabetes | SFEBES2023

Increased risk of obesity programmed by in utero exposure to maternal obesity: the effects of miR-505-5p in the hypothalamus

Furigo Isadora , Dearden Laura , Pantaleao Lucas , Ozanne Susan

In utero exposure to maternal obesity programs an increased risk of obesity. Animal models have shown that offspring obesity is often preceded by increased food intake, however, the mechanisms that mediate these changes are not understood. Using a mouse model of maternal diet-induced obesity we observed increased intake specifically of a high-fat pellet in adult offspring of obese mothers. Through small RNA sequencing, we identified programmed overexpression of miR-505-5p in t...

ea0103oc4.1 | CME Case Presentations 4 | BSPED2024

Reassessing pancreatectomy in diffuse congenital hyperinsulinism: a tale of two brothers with homozygous KCNJ11 variants

Rafique Hamza , Lucas-Herald Angela , Shaikh M Guftar.

Congenital hyperinsulinism (CHI) is a rare but serious disorder characterised by a dysregulated increase in insulin secretion, leading to hypoglycaemia. Existing literature on CHI highlights the importance of early recognition and maintenance of blood glucose levels, due to the risk of neurological damage posed by uncorrected hypoglycaemia. The cases presented highlight the treatment of two brothers who developed neonatal hypoglycaemia due to diffuse CHI resulting from homozyg...

ea0103p82 | Bone 2 | BSPED2024

Cardiovascular risk and achondroplasia: a systematic review

Lo* Irene , Meti* Shraddha , Mason Avril , Lucas-Herald Angela

Introduction: Achondroplasia, caused by a variant in the fibroblast growth factor receptor 3 (FGFR3) gene is the most common form of disproportionate short stature. It is associated with reduced life expectancy, but it is not clear to what extent cardiovascular disease (CVD) is responsible for this. As such, the primary aim of this systematic review was to identify the prevalence of cardiovascular disease in individuals with this condition.Methods: A sys...

ea0081ep734 | Pituitary and Neuroendocrinology | ECE2022

Metabolic and inflammatory parameters for baseline characterization and treatment outcome of prolactinoma patients

Hofbauer Susanna , Ernst Matthias , Horka Laura , Seidenberg Samuel , Regli Lucas , Serra Carlo , Beuschlein Felix , Erlic Zoran

Background: Prolactinomas (PRL) are pituitary adenomas mainly characterized by hyperprolactinemia. In addition to the endocrine effects of prolactin, metabolic alterations have been described in PRL patients. Changes in inflammatory parameters have recently been identified in pituitary adenoma patients. Since both, metabolic (MM) and inflammatory markers (IM) showed promising results in characterization/prognosis of tumor patients, it is tempting to speculate whether those mig...