Searchable abstracts of presentations at key conferences in endocrinology

ea0014p575 | (1) | ECE2007

The GH releasing activity of ghrelin is insensitive to the negative growth hormone (GH) autofeedback in humans

Riganti Fabrizio , Prodam Flavia , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Ghigo Ezio , Broglio Fabio

Growth hormone (GH) secretion is regulated by a complex interplay between GH-releasing hormone (GHRH), somatostatin and several other central and peripheral modulatory signals. Ghrelin has been hypothesized as physiological amplifier of GH pulsatility and acts via mechanisms, at least partially, independent of GHRH and somatostatin. The GH response to GHRH is strongly inhibited by previous administration of recombinant human GH (rhGH), likely as a consequence of a somatostatin...

ea0020p439 | Obesity and Metabolism | ECE2009

The evaluation of metabolic effects following ghrelin and salbutamol administration

Benso Andrea , St-Pierre David H , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Olivetti Ilaria , Ghigo Ezio , Broglio Fabio

Background: The activation of the GHS-R1a receptor by acylated ghrelin (AG) or by synthetic GH secretagogues (GHS), potently stimulates GH release and mediates other neuroendocrine/metabolic effects. Beta-adrenergic receptor agonists negatively influence GH secretion and other metabolic functions. The GH response to AG and GHS is refractory to the inhibitory effect of β2-adrenoceptors activation but no other report has evaluated the interactions between AG and salbutamol ...

ea0016p512 | Obesity | ECE2008

No feedback inhibition of obestatin during acylated ghrelin infusion in humans

Lucatello Barbara , St-Pierre David H. , Settanni Fabio , Olivetti Ilaria , Benso Andrea , Granata Riccarda , Ghigo Ezio , Broglio Fabio

Background: Obestatin is a 27 aa peptide derived from the ghrelin gene. Obestatin was first described to exert anorexigenic effects by decreasing gastric motility in rodent models, however these results have been debated and there is presently only small information regarding its activity and its regulation in humans. Furthermore, its interactions with acylated ghrelin (AG), derived from the same gene, have not been evaluated. Therefore, in these preliminary data, we sought to...

ea0070aep50 | Adrenal and Cardiovascular Endocrinology | ECE2020

Prevalence of primary aldosteronism and association with cardiovascular complications in patients with resistant and refractory hypertension

Parasiliti Caprino Mirko , Lopez Chiara , Prencipe Nunzia , Lucatello Barbara , Settanni Fabio , Giraudo Giuseppe , Rossato Denis , Benso Andrea , Ghigo Ezio , Maccario Mauro

Background: Primary aldosteronism (PA) is the most frequent form of secondary hypertension, with a high prevalence in resistant hypertension (RH), a condition of insufficient blood pressure (BP) control despite a 3-drug based treatment at full dose, including a diuretic. The prevalence of PAin refractory hypertension (ReH), a condition of persistently elevated BP values despite therapy with 5 drugs, is not known.Objective: To investigate the prevalence o...

ea0014p79 | (1) | ECE2007

Unacylated ghrelin (UAG) enhances the early insulin response to meal, improves glucose metabolism and decreases free fatty acids levels in healthy volunteers

Prodam Flavia , Riganti Fabrizio , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Broglio Fabio , Abribat Thierry , Jan van der Lely Aart , Ghigo Ezio

Ghrelin circulates in two different forms. Acylated ghrelin (AG), a natural ligand of the GH Secretagogue receptor (GHS-R) type 1a, exerts several biologic central and peripheral actions including stimulation of GH secretion, but also modulation of insulin secretion, glucose and lipid metabolism. Unacylated ghrelin (UAG), despite unable to bind the GHS-R1a, is biologically active showing some influence in vitro and in vivo on glucose and lipid metabolism likely m...

ea0014p561 | (1) | ECE2007

Effects of CST-8, a synthetic cortistatin analogue, in humans

Benso Andrea , Prodam Flavia , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Jan van der Lely Aart , Deghenghi Romano , Muccioli Giampiero , Ghigo Ezio , Broglio Fabio

Cortistatin (CST), a neuropeptide with high structural homology with somatostatin (SS), binds all SS receptor (SS-R) subtypes but, unlike SS, also shows high binding affinity to ghrelin (GRLN) receptor (GRLN-R). In humans CST exerts the same endocrine activities of SS, suggesting that the activation of the SS-R might mask the potential interaction with the GRLN system.CST-8, a synthetic CST-analogue devoid of any binding affinity to SS-R but capable to b...