Endocrine Abstracts

Aims: To evaluate real-world efficacy of closed-loop systems (CLS) (MinimedTM 780G, DBLG1 -Diabeloop- and Control-IQTM Tandem) as well as to assess those predictive factors related with the achievement of near-normal glycemic control.Methods: A prospective, longitudinal, and observational study was performed. It included T1D adults who initiated CLS between April and December 2021 in our hospital and provided data for ≧3 months (...

Introduction: Graves’ ophthalmopathy (GO) is an orbital autoimmune disorder closely linked to thyroid autoimmunity, mainly Graves’ disease. After an initial progressive inflammatory period (active phase), GO stabilizes and eventually subsides (inactive phase). Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient’s quality of life. Patients with active, mild disease generally benefit from local therapies ...

Background: Preconception planning is essential for a successful pregnancy in women with pregestational diabetes,although many women still do not plan their pregnancies. The rapid outbreak of T2DM among the general population, including women of childbearing age, is one of the largest public health issues. The aim of this study is to describe time trends in preconception planning, obstetric and perinatal outcomesduring the past 8 years in ourpregestational care unit, focusing ...

Introduction: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles and, as a consequence, severely impaired ambulation. Pathophysiology of the disease is based on an increased muscle activity caused by the decreased level of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) due to an autoimmune attack against glutamic acid decarboxylase (GAD); enzyme which is also one of the main autoantigens of type 1 diabetes mel...