Endocrine Abstracts

BackgroundCannabinoid (CB) receptors are expressed in adipocytes. CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). Equivalent studies in brown adipose tissue (BAT) are lacking.ObjectiveWe aimed to compare CB1 and CB2 receptor expression during WAT and BAT adipogenesis and to investi...

GH has diverse direct effects including the induction of lipolysis in adipocytes and mineralisation in bone. Interestingly, pluripotent mesenchymal stem cells can be isolated and cultured from adult bone marrow and induced to differentiate in vitro to both adipocytes and osteoblasts. GHR activation can be coupled to JAK2/STAT5 and the ERK (MAPK) pathway. We have therefore studied the evolution of GHR-associated cell signalling in adult rat BMSC’s during differentia...