Searchable abstracts of presentations at key conferences in endocrinology

ea0012p42 | Diabetes, metabolism and cardiovascular | SFE2006

Cannabinoid receptors in proliferation and differentiation of white and brown adipose tissues

Agarwal N , Rees DA , Ludgate ME

BackgroundCannabinoid (CB) receptors are expressed in adipocytes. CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). Equivalent studies in brown adipose tissue (BAT) are lacking.ObjectiveWe aimed to compare CB1 and CB2 receptor expression during WAT and BAT adipogenesis and to investi...

ea0011oc7 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006

The effect of bone marrow stem cell (BMSC) differentiation on growth hormone receptor (GHR)-associated signalling pathways

Lewis MD , Easter TE , Elford C , Ludgate ME , Evans BAJ , Rees DA , Scanlon MF

GH has diverse direct effects including the induction of lipolysis in adipocytes and mineralisation in bone. Interestingly, pluripotent mesenchymal stem cells can be isolated and cultured from adult bone marrow and induced to differentiate in vitro to both adipocytes and osteoblasts. GHR activation can be coupled to JAK2/STAT5 and the ERK (MAPK) pathway. We have therefore studied the evolution of GHR-associated cell signalling in adult rat BMSCÂ’s during differentia...