Endocrine Abstracts

Klinefelter syndrome (XXY males) is the most common sex chromosome aneuploidy, occurring in about 1 per 500 men. To study the underlying molecular mechanisms caused by the extra X chromosome, we have developed an experimental mouse model for men with Klinefelter’s syndrome. We have demonstrated that adult XXY mice have absence of germ cells, decreased serum testosterone levels, and elevated gonadotropin levels. Testicular failure begins early as a result of massive germ c...