Searchable abstracts of presentations at key conferences in endocrinology

ea0008oc16 | Neuroendocrinology and Reproduction | SFE2004

Sp1 and CREB promote nectin-2 transcription to regulate adherens junctions assembly in the testis

Lui WY , Sze KL , Lee WM

Nectin-2, a major protein component of the adherens junctions (AJs), is found between Sertoli cells and germ cells in the seminiferious epithelium. Recent studies have shown that the expression of nectin-2 gene in testis is crucial to maintain normal spermatogenesis since male knockout mice lacking nectin-2 gene are sterile and possess morphological abnormal spermatozoa. However, the molecular mechanisms governing its basal transcription remain poorly understood. By the use of...