Endocrine Abstracts

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

Objectives: The primary objective was to determine if the use of Contour Next One (CNO) with Contour Diabetes app (APP) was associated with improved self-management using the Summary of Diabetes Self-Care Activities questionnaire (SDSCA). A secondary objective was to establish if CNO and APP together had impact on adherence to self-monitoring blood glucose (BG), indicated by frequency of BG readings and hypoglycemic events. Other secondary objectives were to observe a possible...

Introduction and objectivesType 1 diabetes mellitus (T1DM) is a chronic disease with potential consequences for patients, relatives and ultimately for the healthcare system. The objective of this study is to report the incidence of DM1 in our area as well as assess the characteristics of the patients at the time of diagnosis.Material and Methods: Retrospective descriptive study. Data was collected through the registration of new di...

Context: There is no data on mortality of acromegaly diagnosed in the elderly. Objective: To compare clinical characteristics, GH-related comorbidities, therapeutic approaches and mortality of patients diagnosed before or after 2010 and to assess overall mortality compared with the general Spanish population. Setting: Spanish tertiary care centers.Design, Patients, and Methods: Retrospective evaluation of 118...

Objective: To evaluate the natural history of Rathke’s cleft cysts (RCC).Materials and Methods: A multicenter retrospective clinical practice study of adult patients with radiologically diagnosed RCCs since 2000 in 15 tertiary hospitals (SPAIN-QBR study) with a diameter greater than 5 mm, in whom non-surgical follow-up was decided.Results: A total of 177 patients were followed for 65.8 ± 42.3 months. The mean age was 42.8...

Aim: To evaluate the efficacy of transsphenoidal surgery in patients with Rathke cleft cysts (RCCs), and recurrence rates after follow-upMethods: A multicenter retrospective clinical practice study in patients with RCCs operated through transsphenoidal route and followed in 15 tertiary hospitals (SPAIN-QBR study) during 64.0 ± 49.0 months.Results: A total of 85 patients with a diagnosis of RCCs underwent transsphenoidal surger...

Aim: To evaluate the efficacy of second-line therapies in patients with acromegaly caused by a GH and PRL cosecreting pituitary neuroendocrine tumor (GH&PRL-Pit-NET) and those caused by a GH-Pit-NET.Methods: A multicenter retrospective clinical practice study of 679 patients with acromegaly in follow-up in 33 tertiary hospitals (ACRO-SPAIN study). For this analysis, only patients on treatment with pasireotide or pegvisomant in monotherapy or in combi...

Aim: To investigate the impact of pituitary surgery on glucose metabolism and to identify predictors of diabetes remission after surgery in patients with acromegaly.Methods: A national multicenter retrospective study of acromegaly patients undergoing transsphenoidal surgery for the first time at 33 tertiary Spanish hospitals (ACRO-SPAIN study, n=604) was performed. Surgical remission was evaluated according to the 2000 and 2010 criteria. Glucose...