Searchable abstracts of presentations at key conferences in endocrinology

ea0090p30 | Calcium and Bone | ECE2023

In vitro study of rapid non-genomic effects of 25(OH)D3 in preosteoblastic cells

Donati Simone , Palmini Gaia , Aurilia Cinzia , Falsetti Irene , Marini Francesca , Galli Gianna , Zonefrati Roberto , Iantomasi Teresa , Luisa Brandi Maria

Background: Calcifediol (25(OH)D3), the major circulating form and the direct precursor of the biologically active form of vitamin D, has been identified as an agonist ligand for vitamin D receptor (VDR) with anti-proliferative effects and gene regulatory function despite having a lower receptor affinity respect than the biologically active form of vitamin D3. In fact, recent studies have suggested that 25(OH)D3 can regulate gene expression by ...

ea0090p112 | Endocrine-related Cancer | ECE2023

The involvement of endocannabinoid system in Multiple Endocrine Neoplasia type 1 (MEN1)

Aurilia Cinzia , Donati Simone , Palmini Gaia , Falsetti Irene , Galli Gianna , Zonefrati Roberto , Iantomasi Teresa , Luisa Brandi Maria

Background: Multiple endocrine neoplasia of type 1 (MEN1) is a rare heritable endocrine tumor syndrome that results from biallelic inactivation of the MEN1 gene and the loss of menin protein, that was characterized by a susceptibility to the development of multiple endocrine neoplasms within a single patient. The MEN1 gene screening is helpful in the clinical practice for early genetic diagnosis. Unfortunately, the lack of genotype-phenotype correlation doesnÂ’t allow to f...

ea0090p658 | Endocrine-related Cancer | ECE2023

Cellular models of parathyroid carcinoma: preliminary results

Palmini Gaia , Marini Francesca , Giusti Francesca , Donati Simone , Aurilia Cinzia , Falsetti Irene , Zonefrati Roberto , Perigli Giuliano , Santoro Roberto , Nesi Gabriella , Luisa Brandi Maria

Parathyroid carcinoma (PC) is an extremely rare endocrine malignancy of the parathyroid glands, representing less than 1% of all parathyroid neoplasms. PC is characterized by an excessive secretion of parathyroid hormone (PTH) and severe hypercalcemia. In contrast to parathyroid adenoma, the prognosis for patients with PC is poor, with an overall survival rate of 78-85% and 49-70% respectively at 5 and 10 years after diagnosis, due to the commonly unmanageable hypercalcaemia, ...

ea0070aep180 | Bone and Calcium | ECE2020

Baseline characteristics from the observational paradighm registry of patients with chronic hypoparathyroidism

L Clarke Bart , Rejnmark Lars , Ing Steven , Luisa Brandi Maria , Björnsdottir Sigridur , Hahner Stefanie , Hofbauer Lorenz C , Houillier Pascal , Khan Aliya A , Levine Michael A , Mannstadt Michael , M Shoback Dolores , Vokes Tamara J , Zhang Pinggao , Marelli Claudio , Germak John , Gittoes Neil

PARADIGHM is an actively recruiting, prospective, observational registry (NCT01922440/EUPAS16927). The primary objective is to evaluate the safety and effectiveness of recombinant human parathyroid hormone, rhPTH(1-84), treatment in patients with chronic hypoparathyroidism under routine clinical care. The secondary objective is tocharacterize the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. At enrollment, registry inclusion crite...