Searchable abstracts of presentations at key conferences in endocrinology

ea0088006 | Abstracts | BES2022

NET proteome and bioenergetic profile of PMA- and ionomycin-stimulated neutrophils from people with established type 1 diabetes

Samal Bissenova , Darcy Ellis , Aisha Callebaut , Guy Eelen , Rita Derua , Mijke Buitinga , Chantal Mathieu , Conny Gysemans , Lut Overbergh

Background and aims: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterized by T-cell mediated destruction of the pancreatic insulin-producing beta-cells. Neutrophils, cells of the innate immune system, have been shown to infiltrate the pancreas and undergo neutrophil extracellular trap (NET) formation (NETosis). However, little is known about the involvement of neutrophils and specifically the role of NETosis in the pathophysiology of the disease. Our aim was to...

ea0103p91 | Diabetes 5 | BSPED2024

Strategizing early detection and follow-up for type 1 diabetes: The EDENT1FI project

Besser Rachel , Vercauteren Jurgen , Overbergh Lut , Bonifacio Ezio , Narendran Parth , Bergholdt Regine , Strube Thorsten , Dayan Colin , Niemoeller Elisabeth , Bosi Emanuele , Pociot Flemming , Latres Esther , Hurtado Carmen , Raposo Joao Filipe. , Baccara-Dinet Marie , Reschke Felix , Fogh Kamille , Cohen Ohad , Peakman Mark , Ziegler Anette , Mathieu Chantal

Background and aims: European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) targets early Type 1 Diabetes (T1D) detection to reduce the risk of diabetic ketoacidosis, delay disease progression, improve long-term health outcomes and provide a ‘softer landing’ to insulin therapy. It aims to refine screening and support in early-diagnosed individuals to allow implementation in the clinical care setting.<p class="a...