Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1377 | Pituitary Clinical | ICEECE2012

Array-comparative genomic hybridization in congenital morphological alteration of the pituitary gland

Ribichini D. , Romagnoli M. , Baccini M. , Pasquali R. , Pagotto U. , Seri M.

Congenital morphological alteration of pituitary gland is a rare disease often associated with isolated or multiple hormonal deficiency. So far only few genes have been shown to be implicated in a small number of these cases.Aim of this study was to evaluate putative genetic alteration by an array-based comparative genomic hybridization (array-CGH) in 19 adulthood patients, 16 males and 3 females, affected by congenital morphological alteration of the pi...

ea0029oc12.1 | Obesity Clinical | ICEECE2012

Circulating endocannabinoids are associated to cardiometabolic alterations independently from adiposity

Fanelli F. , Mezzullo M. , Belluomo I. , Di Lallo V. , Colavita M. , Baccini M. , Casadio E. , Ibarra Gasparini D. , Vicennati V. , Pasquali R. , Pagotto U.

Obesity is characterized by an increase of endocannabinoid circulating levels as anandamide (AEA) and 2-arachidonoyl-glycerol (2AG). Whether these lipids represent a biomarker of dysmetabolism or merely reflect the fat mass spill-over is still unclear. After generating rigorous, gender specific, plasma reference intervals by 2D-liquid chromatography-tandem mass spectrometry, we defined the 97.5thcentile of endocannabinoid distribution in the normal population as the cut-off ab...

ea0026p13 | Adrenal cortex | ECE2011

Redefinition of age and sex specific reference intervals of eight serum steroids by liquid chromatography: tandem mass spectrometry (LC–MS/MS)

Fanelli F , Belluomo I , Di Lallo V D , Baccini M , Casadio E , Gasparini D Ibarra , Gambineri A , Pasquali R , Pagotto Uberto

The use of LC–MS/MS quantitative methods in clinical and research laboratories is becoming a well established reality that may overcome specificity and accuracy limits of immunoassays. Nevertheless, among different LC–MS/MS methods an agreement on the values that are to be considered normal or pathologic has not been reached yet, and this is mainly due to differences in LC–MS/MS methods, to the poor or absent availability of reference material and to the selecti...

ea0026p330 | Obesity | ECE2011

Haematic circulating endocannabinoids (ECs) in lean, overweight and obese: the role of the gender

Fanelli F , Di Lallo V D , Belluomo I , Casadio E , Baccini M , Ibarra Gasparini D , Vicennati V , Pasquali R , Pagotto Uberto

A number of publications recently provided measurements of plasma ECs by liquid chromatography–tandem mass spectrometry (LC–MS/MS), however the reported circulating levels in normal subjects are scattered in a very wide range of concentrations. A quantitative LC–MS/MS method for anandamide (AEA), palmitoylethanolamide (PEA), oleoylethanolamyde (OEA) and 2arachidonoyl-glycerol (2AG), chromatographically resolved by its inactive isomer 1AG, was validated in house....