Searchable abstracts of presentations at key conferences in endocrinology

ea0019p387 | Thyroid | SFEBES2009

PTPN22 genotype is a determinant of age of onset of Graves’ disease

Karamat MA , Simmonds MJ , Newby PR , Heward JM , Franklyn JA , Gough SC , Brand OJ

PTPN22, encodes lymphoid tyrosine phosphatise (LYP), an important inhibitor of T lymphocyte activation and has been associated with numerous autoimmune diseases including type 1 diabetes, rheumatoid arthritis, and GravesÂ’ disease (GD). Consistent association has been reported between disease and a non-synonymous SNP +1858 C>T (rs2476601) encoding an Arginine to Tryptophan substitution at amino acid 620 of LYP. Our group was the first to show strong evidence of ...