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ea0081rc10.1 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Insulin resistance as indexed by the estimated glucose disposal rate and liver fat content are correlated in type 1 diabetes

Mertens Jonathan , Spinhoven Maarten , Dirinck Eveline , Vonghia Luisa , Francque Sven , De Block Christophe

Introduction: The prevalence of metabolic syndrome is increasing in individuals with T1D, which could potentiate the development of NAFLD. The pathophysiology of NAFLD in T1D is still unclear, due to the co-existence of predisposing and protective factors. Insulin resistance (IR) is theorized as a key driver of NAFLD.Aim: We investigated the association between liver fat content (LFC), NAFLD, and IR in individuals with T1D. Subjects underwent magnetic re...

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ea0088010 | Abstracts | BES2022

The insulin sensitivity index derived from euglycemic clamps is correlated to liver fat content determined by magnetic resonance spectroscopy in type 1 diabetes*

Jonathan Mertens , Rie Braspenning , Floris Vanhevel , Maarten Spinhoven , Sven Francque , Block Christophe De

Background: Insulin resistance is proposed as a causative factor of non-alcoholic fatty liver disease (NAFLD) in the general population. Reports on NAFLD in type 1 diabetes (T1D) are increasing , but whether insulin resistance is linked to NAFLD in this population needs elucidation. Furthermore, people with T1D are an excellent model to investigate insulin resistance in relation to NAFLD without confounding by autologous insulin production.Aims and Metho...

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Endocrine Abstracts

Insulin resistance as indexed by the estimated glucose disposal rate and liver fat content are correlated in type 1 diabetes

The insulin sensitivity index derived from euglycemic clamps is correlated to liver fat content determined by magnetic resonance spectroscopy in type 1 diabetes*

BiosciAbstracts