Endocrine Abstracts

Introduction: Adrenal haemorrhage is rare. There is a broad spectrum of clinical presentation and aetiology of the condition making it challenging to diagnose. Endocrine dysfunction frequently complicates cases of adrenal haemorrhage. Failure to recognise the condition or its complications can lead to devastating consequences for the patient.Methods: All patients referred to our centre with adrenal haemorrhage between 2004 and 2014 were included in this ...

Introduction: X-linked adrenoleukodystrophy (X-ALD) is caused by a mutation in the ABCD1 gene, which encodes for a peroxisomal very long chain fatty acid (VLCFA) transporter. Clinically, X-ALD can present a wide spectrum of phenotypes, being the most frequent Adrenomyeloneuropathy, with ataxia, spastic paraparesis, sexual and sphincter dysfunction. Adrenocortical insufficiency (AI) occurs mainly in paediatric age and it can be the first manifestation of the disease in some cas...

Obesity is a major health problem commonly associated with severe comorbidities, including insulin resistance and type 2 diabetes mellitus (T2DM). Emerging evidence suggests that production and secretion of certain micro RNAs (miRNAs) are dysregulated under adverse metabolic conditions and might exert a key role in the development and progression of different metabolic-related pathologies. However, the alteration of the plasma miRNA profile under obesity condition and its path...