Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1094 | Thyroid cancer | ECE2016

Thyroid nodule ultrasound: which indication for FNA? a prospective study

Riganti Fabrizio , Bonelli Nadia , Rossetto Ruth , Pacchioni Donatella , Viberti Laura , Maccario Mauro , Ghigo Ezio , Garberoglio Roberto

Introduction: Thyroid nodules are discovered by ultrasound (US) in a large percentage of population. In most cases they are benign and asymptomatic. When to perform or not a fine-needle-aspiration (FNA) is still matter of debate. Aim of this study was to evaluate the usefulness of a easy-to-use US classification, based on three US classes.Methods: We prospectively evaluated US features of 1118 thyroid nodules, allocating each nodule in one of three class...

ea0022p668 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

IGF1 levels as predictor factor of metabolic derangement in adult patients with severe GH deficiency

Gasco Valentina , Beccuti Guglielmo , Rovere Silvia , Marotta Filippa , Aimaretti Gianluca , Maccario Mauro , Grottoli Silvia , Ghigo Ezio

GH deficiency (GHD) in adults leads to impairment in body composition and function, as well as to deranged lipoprotein and carbohydrate metabolism implying increased cardiovascular morbidity. The morphologic and metabolic alterations in GHD syndrome are more marked in patients with the most severe GHD, even when evaluated by maximal provocative test such as GHRH + arginine. IGF1 synthesis and secretion are function of the GH status but also of major metabolic factors such as i...

ea0081rc7.2 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Development and internal validation of a predictive score for the diagnosis of central adrenal insufficiency when morning cortisol is in the grey zone

Bioletto Fabio , Maria Berton Alessandro , Varaldo Emanuele , Cuboni Daniela , Bona Chiara , Parasiliti Caprino Mirko , Prencipe Nunzia , Ghigo Ezio , Grottoli Silvia , Maccario Mauro , Gasco Valentina

Background: When evaluating a patient for central adrenal insufficiency (CAI), there is a wide range of morning cortisol values for which no final conclusion on hypothalamus-pituitary-adrenal (HPA) axis function can be drawn; in these cases, a stimulation test is required. Aim of this study was to develop an integrated model for the prediction of CAI when morning cortisol is in the grey zone, here defined as 40.0-160.0 μg/l.Methods: Overall, 119 pat...

ea0081rc13.3 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Steroidomic approach for the characterization of patients with non-alcoholic fatty liver disease

Parasiliti Caprino Mirko , Rosso Chiara , Ponzetto Federico , Paolo Caviglia Gian , Lopez Chiara , Armandi Angelo , Maria Saracco Giorgio , Ghigo Ezio , Bugianesi Elisabetta , Maccario Mauro

Introduction: The onset and progression of liver damage in non-alcoholic fatty liver disease (NAFLD) is tightly associated with metabolic derangements. Steroids may affect lipid metabolism but their alterations in the setting of NAFLD remain to be fully explored.Patients and Methods: We analyzed data from 121 patients with biopsy-proven NAFLD and 108 controls (CT). A panel of 26 steroids (including glucocorticoids, mineralocorticoids, androgens, and prog...

ea0081p271 | Adrenal and Cardiovascular Endocrinology | ECE2022

The accuracy of adjusted unconventional indices for the assessment of selectivity and lateralization of adrenal vein sampling in the subtype diagnosis of primary aldosteronism

Bollati Martina , Parasiliti-Caprino Mirko , Bioletto Fabio , Ceccato Filippo , Lopez Chiara , Di Carlo Maria Chiara , Voltan Giacomo , Rossato Denis , Giraudo Giuseppe , Scaroni Carla , Ghigo Ezio , Maccario Mauro

Objective: This study aimed to evaluate the performance of simple and clinical/imaging-corrected unconventional indices in predicting the selectivity of adrenal vein sampling (AVS) and the lateralization of aldosterone hypersecretion in patients with primary aldosteronism (PA).Methods: Data of all consecutive patients with a proven diagnosis of PA who underwent AVS for subtype differentiation in two Italian referral centers were analyzed retrospectively....

ea0081p397 | Pituitary and Neuroendocrinology | ECE2022

The cut-off limits of GH response to GHRH + arginine test related to body mass index for the diagnosis of adult GH deficiency: do we need to review our diagnostic criteria?

Cuboni Daniela , Varaldo Emanuele , Bioletto Fabio , Maria Berton Alessandro , Bona Chiara , Prencipe Nunzia , Ghigo Ezio , Maccario Mauro , Grottoli Silvia , Gasco Valentina

Introduction: The diagnosis of GH deficiency (GHD) in adults is based on a reduced GH response to provocative tests. The proportion of patients with low GH response to provocative tests increases with the number of other pituitary hormone deficiencies and several studies involving panhypopituitary patients have shown that under certain circumstances GH stimulation tests may be unnecessary to diagnose GHD.Objective: Aim of this study was to re-evaluate th...

ea0070aep50 | Adrenal and Cardiovascular Endocrinology | ECE2020

Prevalence of primary aldosteronism and association with cardiovascular complications in patients with resistant and refractory hypertension

Parasiliti Caprino Mirko , Lopez Chiara , Prencipe Nunzia , Lucatello Barbara , Settanni Fabio , Giraudo Giuseppe , Rossato Denis , Benso Andrea , Ghigo Ezio , Maccario Mauro

Background: Primary aldosteronism (PA) is the most frequent form of secondary hypertension, with a high prevalence in resistant hypertension (RH), a condition of insufficient blood pressure (BP) control despite a 3-drug based treatment at full dose, including a diuretic. The prevalence of PAin refractory hypertension (ReH), a condition of persistently elevated BP values despite therapy with 5 drugs, is not known.Objective: To investigate the prevalence o...

ea0022p18 | Adrenal | ECE2010

The aldosterone renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma

Rossi GianPaolo , Barisa Marlena , Desideri GiovanBattista , Letizia Claudio , Maccario Mauro , Morganti Alberto , Palumbo Gaetana , Patalano Anna , Realdi Anna , Roman Elisabetta , Seccia Teresa Maria , Pessina Achille Cesare

The screening for primary aldosteronism (PA) is based on the aldosterone/renin ratio (ARR), which is calculated with the plasma renin activity (PRA) as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains uncertain.Aim of the study was to head-to-head compare the ARR based on PRA (ARR-P) to on DRA (ARR-D), at baseline and post-captopril, for identifying aldosterone-producin...

ea0014p205 | (1) | ECE2007

Daily and nightly urinary free cortisol ratio as a marker of the hypothalamic-pituitary-adrenal (HPA) axis activity in abdominal obesity

Vicennati Valentina , Pagotto Uberto , Ambrosi Bruno , Maccario Mauro , Uberti Ettore Degli , Boscaro Marco , Cavagnini Francesco , Mantero Franco , Armanini Decio , Vettor Roberto , Marugo Mario , Pasquali Renato

Abdominal obese (AO) women might have a hyperactivation of the HPA axis. The limitations of previous studies have been often represented by the limited and heterogeneous number of patients enrolled. Our aim was to asses urinary free cortisol (UFC) output during daily and nightly hours in a large cohort of AO women vs. normal weight controls (CT). 107 AO women and 37 CT were enrolled in the study. In basal condition, each subject underwent OGTT, biochemical determinations. Each...

ea0081rc13.7 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

An observational retrospective study on the association of urine metanephrine levels with cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma

Di Carlo Maria Chiara , Parasiliti Caprino Mirko , Lopez Chiara , Bollati Martina , Bioletto Fabio , Sola Chiara , Ponzetto Federico , Gesmundo Iacopo , Settanni Fabio , Ghigo Ezio , Mengozzi Giulio , Maccario Mauro , GIORDANO Roberta

Background: Several studies argued that the cardiovascular evaluation of patients with nonfunctioning adrenal incidentaloma is of particular importance, even if a direct association seems difficult to underline.Objective: We aimed to evaluate the possibility of stratifying cardiometabolic risk through metanephrine levels in patients with incidentally discovered nonfunctioning adrenal adenoma.Design: In this retrospective cross-sect...