Endocrine Abstracts

Aim: HMβ is a metabolite of leucine commonly used by athletes and in medical practice in order to increase muscle mass and/or minimize protein degradation. We have previously shown that chronic intake of HMβ increases GH synthesis and secretion in rats, which might account to its anabolic effect. However HMβ-treated rats, although normoglycemic, exhibited hyperinsulinemia, suggesting an apparent insulin resistance (IR) state. The present study attempted to inves...