Endocrine Abstracts

Hypercalcaemia during pregnancy is unusual and primary hyperparathyroidism is the commonest cause: we present a more unusual case.Case history: 29-year woman, 34 weeks pregnant, was admitted with hypertension and oedema. She had gestational diabetes managed with diet alone. Initial calcium level was normal; it gradually increased in the next few days though this was not noted. She was diagnosed with preeclampsia and treated with steroids for foetal lung ...

A 63 year old female was referred to ophthalmology in December 2007 with a 10 day history of redness, itching and watering of her left eye: the eye had congestion, chemosis and mild proptosis, and ocular movements were mildly restricted. There was no reduction in visual acuity. MRI in January reported no intraocular or intraorbital lesion, and an inflammatory cause was sought - possibly thyroid eye disease. She did not improve on pressure lowering treatments but had some impro...

Background: Nephrogenic diabetes insipidus (DI) is characterized by polyuria with dilute urine due to the inability of the principal cells of the renal collecting ducts to respond to antidiuretic hormone and concentrate urine. It can be drug-induced and several chemotherapeutic agents, including the platinum derivative cisplatin and the antimetabolite pemetrexed, have been reported to cause nephrogenic DI, presumably via tubular damage.Case presentation:...

A 40 year old man with CAH and significant needle phobia presented with left leg pain in January 2011. He had been discharged from follow up at another trust. Medications were hydrocortisone 10 mg BD and fludrocortisone 100 mcg OD. Admission haemoglobin was 19.9 g/dl, haematocrit 0.554. A thorough work up to investigate causes of polycythaemia revealed the only significant abnormality as a testosterone of 45.7 nmol/L (8–27), with low gonadotrophins. The blood sample for 1...

We present the case of an 80-year-old man found to have a non-functioning pituitary macroadenoma causing secondary adrenal insufficiency and hypogonadism in 2006. Thyroid function and prolactin levels were normal. With hydrocortisone replacement he was doing well. There was no visual field defect and he continued with conservative management. On enquiring about testosterone treatment, it had been started in Oct 2008, but discontinued within a month as there was no change in hi...

Case History: We describe a case of a 30-year-old female who presented at 8 weeks postpartum with history of altered behaviour, clouding of consciousness and status epilepticus. She had been diagnosed with autoimmune graves thyroid disease and was commenced on carbimazole prior to this episode. She was treated as meningoencephalitis. Also, consideration was given for possibility of thyroid storm and post-partum eclampsia. She was intubated and ventilated, treated with IV acycl...

Introduction: Multiple myeloma (MM) is a haematological disorder characterised by an aberrant rise in monoclonal paraprotein. Intrasellar plasmacytomas can be infrequent MM manifestations. They are challenging to diagnose and frequently mimic pituitary adenomas; however rarely present with pituitary apoplexy. We describe a patient with pituitary apoplexy-like symptoms, subsequently diagnosed with MM, whose intrasellar mass entirely resolved after chemotherapy....

A 24 year old female presented to her general practitioner with general malaise. She had a genetic diagnosis of hereditary non-polyposis colorectal cancer (Lynch syndrome), with no colonic lesions detected on screening. Routine biochemistry revealed a potassium of 2.1mmol/l, requiring admission for urgent investigation and intravenous replacement. Further clinical assessment found a past history of severe acute thoracic back pain (3-months prior to presentation), weight gain a...

Tumour induced hypoglycaemia is a rare disorder occurring in cancer patients caused by variety of tumours including islet and non-islet tumours. Non-islet cell tumour induced hypoglycaemia (NICTH) is rare paraneoplastic disorders normally associated with pleural solitary fibrous tumour but can also rarely occur in extra thoracic site.We describe an 86-year-old man not known to have diabetes mellitus who presented with 3-month history of early morning hea...