Searchable abstracts of presentations at key conferences in endocrinology

ea0034p255 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Serum ferritin levels are correlated with total adiposity, but not BMI in obese males

Zariwala M Gulrez , Kosicka Ania , Mackenzie Richard , Renshaw Derek

According to the World Health Organisation iron deficiency is the most prevalent form of under-nutrition worldwide. Historically, the causes of iron deficiency were related principally to nutritional deficiencies and this remains a significant factor in many parts of the developing world. However, obesity is also a known cause of iron deficiency and is increasingly correlated with altered iron status and iron deficiency in affected individuals. As the obesity epidemic spreads ...

ea0031p136 | Cytokines and growth factors | SFEBES2013

Effect of acute hypoxia upon myostatin expression in healthy individuals

Elliott Bradley , Renshaw Derek , Getting Stephen , Watt Peter , Mackenzie Richard

We previously showed acute hypoxic conditions result in atrophy of myotubes in vitro. Chronic hypoxic exposure in vivo induces muscular atrophy in healthy mountaineering individuals and patients with COPD. Myotubes in vitro increase myostatin expression in response to hypoxic exposure. Further, hypoxic COPD patients show cachexia and increased serum myostatin expression. However, in vivo results are cofounded by disease factors in COPD patie...

ea0025p140 | Diabetes, metabolism and cardiovascular | SFEBES2011

Insulin sensitivity and cytokine response to different exercise modalities in hypoxia in type 2 diabetics

Mackenzie Richard , Maxwell Neil , Elliott Bradley , Brickley Gary , Watt Peter

Continuous aerobic exercise improves glucose tolerance in type 2 diabetics (T2D), with greater improvements during exercise in hypoxia. Continuous exercise has been linked with poor adherence. Positive effects with intermittent exercise (IE) with reduced time commitments would have clear benefits. Exercise and hypoxia both increase pro-inflammatory cytokines, potentially reducing benefits of hypoxia. This study aimed to establish the effects of IE under hypoxic conditions in T...

ea0031p191 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Novel inositol pyrophosphate and insulin sensitivity in response to muscle contraction in glucose intolerant humans

Naufahu Jane , Watt Peter , Mellish Louise , Elliott Bradley , Kerekgyarto Anna , Mackenzie Richard

Peripheral insulin resistance is a major defect associated with glucose intolerance and type two diabetes. Yet the mechanism(s) responsible for this defect remain to be determined. Inositol pyrophosphate (IP7) is formed via the enzyme IP6K1 from IP6. The inhibition of Akt, and the potential decrease in insulin signalling, through the binding of IP7 to the Akt PH domain represents an exciting research area.Firstly, we will characterise this mechanism in h...

ea0028p193 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Zariwala Mohammed , Renshaw Derek

Annexin A1 (AnxA1), an endogenous glucocorticoid regulated protein, is a pivotal homeostatic regulator of the magnitude of the inflammatory response. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with waist to hip ratio (P=0.017). Given that low-level systemic inflammation is seen in metabolic syndrome-associated chronic pathologies, here, we investigate if AnxA1 is also involved in the regulation of adipose tissue infla...

ea0025p133 | Diabetes, metabolism and cardiovascular | SFEBES2011

Plasma Annexin A1 (AnxA1) is inversely correlated with waist to hip ratio in healthy males

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Flower Rod , Renshaw Derek

The escalating public health problem represented by obesity has spurred multidisciplinary research into adipose tissue and importantly, the molecular biology of the adipocyte. Recent studies suggest that obesity related metabolic disorders are characterised by chronic mild inflammation as a result of adipocytokine production from fat tissue leading to dysregulation in the pro/anti-inflammatory systemic balance. Adipokines and pro-inflammatory markers are implicated in insulin ...